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  B1+-correction of magnetization transfer saturation maps optimized for 7T postmortem MRI of the brain

Lipp, I., Kirilina, E., Edwards, L., Pine, K., Jäger, C., Gräßle, T., et al. (2023). B1+-correction of magnetization transfer saturation maps optimized for 7T postmortem MRI of the brain. Magnetic Resonance in Medicine, 89(4), 1385-1400. doi:10.1002/mrm.29524.

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 Creators:
Lipp, Ilona1, Author                 
Kirilina, Evgeniya1, Author                 
Edwards, Luke1, Author                 
Pine, Kerrin1, Author                 
Jäger, Carsten1, 2, Author                 
Gräßle, Tobias3, Author
EBC Consortium1, Author
Weiskopf, Nikolaus1, 4, Author                 
Helms, Gunther1, 5, Author           
Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
2Paul Flechsig Institute for Brain Research, University of Leipzig, Germany, ou_persistent22              
3Research Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany, ou_persistent22              
4Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
5Medical Radiation Physics, Department of Clinical Sciences, Lund University, Denmark, ou_persistent22              

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Free keywords: MRI; Calibration; Chimpanzee; Magnetization transfer; Postmortem; Transmit field; Ultra high-field.
 Abstract: Purpose: Magnetization transfer saturation (MTsat) is a useful marker to probe tissue macromolecular content and myelination in the brain. The increased B+1-inhomogeneity at 7T and significantly larger saturation pulse flip angles which are often used for postmortem studies exceed the limits where previous MTsat B+1-correction methods are applicable. Here, we develop a calibration-based correction model and procedure, and validate and evaluate it in postmortem 7T data of whole chimpanzee brains.

Theory: The B+1 dependence of MTsat was investigated by varying the off-resonance saturation pulse flip angle. For the range of saturation pulse flip angles applied in typical experiments on postmortem tissue, the dependence was close to linear. A linear model with a single calibration constant C is proposed to correct bias in MTsat by mapping it to the reference value of the saturation pulse flip angle.
Methods: C was estimated voxel-wise in five postmortem chimpanzee brains. "Individual-based global parameters" were obtained by calculating the mean C within individual specimen brains and "group-based global parameters" by calculating the means of the individual-based global parameters across the five brains.

Results: The linear calibration model described the data well, though C was not entirely independent of the underlying tissue and B+1. Individual-based correction parameters and a group-based global correction parameter ( C=1.2) led to visible, quantifiable reductions of B+1-biases in high-resolution MTsat maps.

Conclusion: The presented model and calibration approach effectively corrects for B+1 inhomogeneities in postmortem 7T data.

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Language(s): eng - English
 Dates: 2022-10-062022-07-012022-10-252022-11-132023-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/mrm.29524
Other: epub 2022
PMID: 36373175
 Degree: -

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Project name : -
Grant ID : 347592254 (WE5046/4-2,KI1337/2-2), 446291874
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : -
Project name : -
Grant ID : 616905
Funding program : Seventh Framework Programme
Funding organization : -
Project name : -
Grant ID : 2014-6193
Funding program : -
Funding organization : Vetenskapsrådet

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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 89 (4) Sequence Number: - Start / End Page: 1385 - 1400 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149