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At the Origin of Life: How Did Folded Proteins Evolve?

Lupas, A. (2008). At the Origin of Life: How Did Folded Proteins Evolve? In M. Vingron, & L. Wong (Eds.), Research in Computational Molecular Biology: 12th Annual International Conference, RECOMB 2008, Singapore, March 30 - April 2, 2008, Proceedings (pp. 272). Berlin, Germany: Springer.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-710D-8 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-710E-7

Genre: Conference Paper

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Creators:
Lupas, A¹, Author

Affiliations:
1Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375791

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Abstract: Proteins are essential building blocks of living cells; indeed, life can be viewed as resulting substantially from the chemical activity of proteins. Because of their importance, it is hardly surprising that ancestors for most proteins observed today were already present at the time of the ‘last common ancestor’, a primordial organism from which all life on Earth is descended. Yet folded proteins are too complex to have arisen de novo. How then did they evolve? We are pursuing the hypothesis that folded proteins evolved by fusion and recombination from an ancestral set of peptides, which emerged in the context of RNA-dependent replication and catalysis (the “RNA world”). Systematic studies should allow a description of this ancient peptide set in the same way in which ancient vocabularies have been reconstructed from the comparative study of modern languages.

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Dates: Date issued: 2008

Publication Status: Issued

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Identifiers: DOI: 10.1007/978-3-540-78839-3_23

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Title: 12th Annual International Conference on Research in Computational Molecular Biology (RECOMB 2008)

Place of Event: Singapore

Start-/End Date: 2008-03-30 - 2008-04-02

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Title: Research in Computational Molecular Biology: 12th Annual International Conference, RECOMB 2008, Singapore, March 30 - April 2, 2008, Proceedings

Source Genre: Proceedings

Creator(s):
Vingron, M, Editor
Wong, L, Editor

Affiliations:
-

Publ. Info: Berlin, Germany : Springer

Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 272 Identifier: ISBN: 978-3-540-78838-6
DOI: 10.1007/978-3-540-78839-3

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Title: Lecture Notes in Computer Science

Other : Lect. Notes Comput. Sci.

Source Genre: Series

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Publ. Info: Berlin : Springer

Pages: - Volume / Issue: 4955 Sequence Number: - Start / End Page: - Identifier: ISSN: 0302-9743
CoNE: https://pure.mpg.de/cone/journals/resource/954928560451