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キーワード:
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要旨:
The genome contains an organism’s complete set of instructions for development, survival and reproduction. “Decoding” these instructions remains one of the biggest challenges in biology with enormous implications for medicine, agriculture, and conservation. Leveraging the unique advantages of the threespine stickleback fish system, I’ll describe the approaches we’ve been using to identify the molecular basis and common molecular mechanisms underlying gene regulation, trait variation, physiological and disease phenotypes and survival in different marine and freshwater environments. Combining diverse genomic, transcriptomic and epigenomic datasets I’ll discuss the importance of cis-regulation of the non-coding regulatory genome as mechanisms underlying divergent adaptation to different habitats.
