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  What is rate-limiting during sustained synaptic activity: Vesicle supply or the availability of release sites

Neher, E. (2010). What is rate-limiting during sustained synaptic activity: Vesicle supply or the availability of release sites. Frontiers in Synaptic Neuroscience, 2: 144. doi:10.3389/fnsyn.2010.00144.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-31E8-7 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-31E9-6
Genre: Journal Article

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fnsyn-02-00144.pdf (Publisher version), 2MB
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 Creators:
Neher, Erwin1, Author                 
Affiliations:
1Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: For some types of synapses the availability of release-ready vesicles is a limiting factor during ongoing activity. Synaptic strength in this case is determined both by the recruitment of such vesicles and the probability of their release during an action potential. Here it is argued that not the availability of vesicles is the limiting factor for recruitment, but rather the availability of specific sites to which vesicles can dock.

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Language(s): eng - English
 Dates: 2010-09
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnsyn.2010.00144
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Title: Frontiers in Synaptic Neuroscience
Source Genre: Journal
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Publ. Info: Frontiers Research Foundation
Pages: - Volume / Issue: 2 Sequence Number: 144 Start / End Page: - Identifier: Other: ISSN
CoNE: https://pure.mpg.de/cone/journals/resource/1663-3563