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  Neuropsychiatric phenotype of post COVID-19 syndrome in non-hospitalized patients

Lier, J., Stoll, K., Obrig, H., Baum, P., Deterding, L., Bernsdorff, N., et al. (2022). Neuropsychiatric phenotype of post COVID-19 syndrome in non-hospitalized patients. Frontiers in Neurology, 13: 988359. doi:10.3389/fneur.2022.988359.

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 Urheber:
Lier, Julia1, Autor
Stoll, Kristin1, Autor
Obrig, Hellmuth2, Autor           
Baum, Paul3, Autor
Deterding, Lea4, Autor
Bernsdorff, Nora1, Autor
Hermsdorf, Franz1, Autor
Kunis, Ines1, Autor
Bräsecke, Andrea1, Autor
Herzig, Sabine2, Autor           
Schroeter, Matthias L.2, Autor           
Thöne-Otto, Angelika2, Autor
Riedel-Heller, Steffi G.5, Autor
Laufs, Ulrich3, Autor
Wirtz, Hubert4, Autor
Classen, Joseph1, Autor
Saur, Dorothee1, Autor
Affiliations:
1Department of Neurology, University Hospital Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Department for Cardiology, University Hospital Leipzig, Germany, ou_persistent22              
4Department of Gastroenterology, Hepatology, Infectious Diseases, Pneumology, University Hospital Leipzig, Germany, ou_persistent22              
5Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              

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Schlagwörter: COVID-19; MFI-20; PCFS; Neuropsychiatric disorders; Post COVID-19 syndrome
 Zusammenfassung: The post COVID-19 syndrome (PCS) is an emerging phenomenon worldwide with enormous socioeconomic impact. While many patients describe neuropsychiatric deficits, the symptoms are yet to be assessed and defined systematically. In this prospective cohort study, we report on the results of a neuropsychiatric consultation implemented in May 2021. A cohort of 105 consecutive patients with merely mild acute course of disease was identified by its high symptom load 6 months post infection using a standardized neurocognitive and psychiatric-psychosomatic assessment. In this cohort, we found a strong correlation between higher scores in questionnaires for fatigue (MFI-20), somatization (PHQ15) and depression (PHQ9) and worse functional outcome as measured by the post COVID functional scale (PCFS). In contrast, neurocognitive scales correlated with age, but not with PCFS. Standard laboratory and cardiopulmonary biomarkers did not differ between the group of patients with predominant neuropsychiatric symptoms and a control group of neuropsychiatrically unaffected PCS patients. Our study delineates a phenotype of PCS dominated by symptoms of fatigue, somatisation and depression. The strong association of psychiatric and psychosomatic symptoms with the PCFS warrants a systematic evaluation of psychosocial side effects of the pandemic itself and psychiatric comorbidities on the long-term outcome of patients with SARS-CoV-2 infection.

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Sprache(n): eng - English
 Datum: 2022-07-072022-08-292022-09-27
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.3389/fneur.2022.988359
Anderer: eCollection 2022
PMID: 36237627
PMC: PMC9552839
 Art des Abschluß: -

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Titel: Frontiers in Neurology
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Lausanne, Switzerland : Frontiers Research Foundation
Seiten: - Band / Heft: 13 Artikelnummer: 988359 Start- / Endseite: - Identifikator: ISSN: 1664-2295
CoNE: https://pure.mpg.de/cone/journals/resource/1664-2295