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  Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders

Hettwer, M., Larivière, S., Park, B. Y., van den Heuvel, O. A., Schmaal, L., Andreassen, O. A., et al. (2022). Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders. Nature Communications, 13: 6851. doi:10.1038/s41467-022-34367-6.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-758C-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-31FC-0
Genre: Journal Article

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 Creators:
Hettwer, Meike1, Author           
Larivière, S.2, Author
Park, B. Y.2, Author
van den Heuvel, O. A.2, Author
Schmaal, L.2, Author
Andreassen, O. A.2, Author
Ching, C. R. K.2, Author
Hoogman, M.2, Author
Buitelaar, J.2, Author
van Rooij, D.2, Author
Veltman, D. J.2, Author
Stein, D. J.2, Author
Franke, B.2, Author
van Erp, T. G. M.2, Author
ENIGMA ADHD Working Group, Author              
ENIGMA Autism Working Group, Author              
ENIGMA Bipolar Disorder Working Group, Author              
ENIGMA Major Depression Working Group, Author              
ENIGMA OCD Working Group, Author              
ENIGMA Schizophrenia Working Group, Author              
van Rooij, D.2, Authorvan den Heuvel, O. A.2, Authorvan Erp, T. G. M.2, AuthorJahanshad, N.2, AuthorThompson, P. M.2, AuthorThomopoulos, S. I.2, AuthorBethlehem, R. A. I.2, AuthorBernhardt, B. C.2, AuthorEickhoff, S. B.2, AuthorValk, Sofie L.1, Author                  more..
Affiliations:
1Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
2External Organizations, ou_persistent22              

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Free keywords: Cognitive neuroscience; Neurodevelopmental disorders; Psychiatric disorders
 Abstract: Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters. Manifold learning revealed frontal-to-temporal and sensory/limbic-to-occipitoparietal transdiagnostic gradients, differentiating shared illness effects on cortical thickness along these axes. The principal gradient aligned with a normative cortical thickness covariance gradient and established a transcriptomic link to cortico-cerebello-thalamic circuits. Moreover, transdiagnostic gradients segregated functional networks involved in basic sensory, attentional/perceptual, and domain-general cognitive processes, and distinguished between regional cytoarchitectonic profiles. Together, our findings indicate that shared illness effects occur in a synchronized fashion and along multiple levels of hierarchical cortical organization.

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Language(s): eng - English
 Dates: 2022-02-162022-10-242022-11-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41467-022-34367-6
PMID: 36369423
PMC: PMC9652311
 Degree: -

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Project name : -
Grant ID : U54 EB020403
Funding program : -
Funding organization : National Institutes of Health (NIH)
Project name : -
Grant ID : U54 MH091657
Funding program : Human Connectome Project
Funding organization : -
Project name : -
Grant ID : NRF-2021R1F1A1052303; NRF-2022R1A5A7033499
Funding program : -
Funding organization : National Research Foundation of Korea
Project name : -
Grant ID : 2022-0-00448; 2020-0-01389; RS-2022-00155915; 2021-0-02068
Funding program : -
Funding organization : Korea Government
Project name : -
Grant ID : IBS-R015-D1
Funding program : -
Funding organization : Institute for Basic Science
Project name : -
Grant ID : 91619115
Funding program : -
Funding organization : Netherlands Organization for Scientific Research (NWO)
Project name : -
Grant ID : 115300; 777394
Funding program : -
Funding organization : European Autism Interventions
Project name : -
Grant ID : 847818
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : NI17-039
Funding program : -
Funding organization : SickKids Foundation
Project name : -
Grant ID : Discovery-1304413
Funding program : -
Funding organization : Natural Sciences and Engineering Research Council of Canada (NSERC)
Project name : -
Grant ID : FDN-154298; PJT- 174995
Funding program : -
Funding organization : Canadian Institutes of Health Research (CIHR)

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 13 Sequence Number: 6851 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723