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  Reliability of multi-parameter mapping (MPM) in the cervical cord: A multi-center multi-vendor quantitative MRI study

Seif, M., Leutritz, T., Schading, S., Emmengger, T., Curt, A., Weiskopf, N., et al. (2022). Reliability of multi-parameter mapping (MPM) in the cervical cord: A multi-center multi-vendor quantitative MRI study. NeuroImage, 264: 119751. doi:10.1016/j.neuroimage.2022.119751.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000B-75A4-8 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-15FE-E
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 Urheber:
Seif, Maryam1, 2, Autor           
Leutritz, Tobias2, Autor                 
Schading, Simon1, Autor
Emmengger, Tim1, Autor
Curt, Armin1, Autor
Weiskopf, Nikolaus2, 3, Autor                 
Freund, Patrick1, 2, 4, Autor                 
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
4Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, United Kingdom, ou_persistent22              

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Schlagwörter: Quantitative MRI; Multi-center study; Reproducibility; Spinal cord; Brain; Traveling heads study
 Zusammenfassung: MRI based multicenter studies which target neurological pathologies affecting the spinal cord and brain – including spinal cord injury (SCI) – require standardized acquisition protocols and image processing methods. We have optimized and applied a multi-parameter mapping (MPM) protocol that simultaneously covers the brain and the cervical cord within a traveling heads study across six clinical centers (Leutritz et al., 2020). The MPM protocol includes quantitative maps (magnetization transfer saturation (MT), proton density (PD), longitudinal (R1), and effective transverse (R2*) relaxation rates) sensitive to myelination, water content, iron concentration, and morphometric measures, such as cross-sectional cord area. Previously, we assessed the repeatability and reproducibility of the brain MPM data acquired in the five healthy participants who underwent two scan-rescans (Leutritz et al., 2020). This study focuses on the cervical cord MPM data derived from the same acquisitions to determine its repeatability and reproducibility in the cervical cord. MPM matrices of the cervical cord were generated and processed using the hMRI and the spinal cord toolbox. To determine reliability of the cervical MPM data, the intra-site (i.e., scan-rescan) coefficient of variation (CoV), inter-site CoV, and bias within region of interests (C1, C2 and C3 levels) were determined. The range of the mean intra- and inter-site CoV of MT, R1 and PD was between 2.5% and 12%, and between 1.1% and 4.0% for the morphometric measures. In conclusion, the cervical MPM data showed a high repeatability and reproducibility for key imaging biomarkers and hence can be employed as a standardized tool in multi-center studies, including clinical trials.

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Sprache(n): eng - English
 Datum: 2022-11-072022-08-082022-11-122022-11-132022-12-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1016/j.neuroimage.2022.119751
Anderer: epub 2022
PMID: 36384206
 Art des Abschluß: -

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Projektname : -
Grant ID : 681094
Förderprogramm : Horizon 2020
Förderorganisation : European Union
Projektname : -
Grant ID : 32NE30_173678
Förderprogramm : -
Förderorganisation : ERA-NET NEURON
Projektname : -
Grant ID : WFL-CH-007/14; WFL-CH-19/20
Förderprogramm : -
Förderorganisation : Wings for life charity
Projektname : -
Grant ID : IRP-158; IRP-2022-01-158
Förderprogramm : -
Förderorganisation : International Foundation for Research
Projektname : -
Grant ID : 616905
Förderprogramm : Seventh Framework Programme
Förderorganisation : European Union
Projektname : -
Grant ID : 15.0137
Förderprogramm : -
Förderorganisation : Swiss State Secretariat for Education, Research and Innovation (SERI)
Projektname : -
Grant ID : 01EW1711B
Förderprogramm : -
Förderorganisation : Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : 181362
Förderprogramm : Eccellenza fellowship
Förderorganisation : Swiss National Science Foundation (SNSF)

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 264 Artikelnummer: 119751 Start- / Endseite: - Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166