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  Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic

Blaurock, C., Breithaupt, A., Weber, S., Wylezich, C., Keller, M., Mohl, B.-P., et al. (2022). Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic. Scientific Reports, 12: 15069. doi:10.1038/s41598-022-19222-4.

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Blaurock, Claudia, Author
Breithaupt, Angele, Author
Weber, Saskia, Author
Wylezich, Claudia, Author
Keller, Markus, Author
Mohl, Björn-Patrick, Author
Görlich, Dirk1, Author           
Groschup, Martin H., Author
Sadeghi, Balal, Author
Höper, Dirk, Author
Mettenleiter, Thomas C., Author
Balkema-Buschmann, Anne, Author
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1Department of Cellular Logistics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350135              

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 Abstract: Golden Syrian hamsters (Mesocricetus auratus) are used as a research model for severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Millions of Golden Syrian hamsters are also kept as pets in close contact to humans. To determine the minimum infective dose (MID) for assessing the zoonotic transmission risk, and to define the optimal infection dose for experimental studies, we orotracheally inoculated hamsters with SARS-CoV-2 doses from 1 * 105 to 1 * 10-4 tissue culture infectious dose 50 (TCID50). Body weight and virus shedding were monitored daily. 1 * 10-3 TCID50 was defined as the MID, and this was still sufficient to induce virus shedding at levels up to 102.75 TCID50/ml, equaling the estimated MID for humans. Virological and histological data revealed 1 * 102 TCID50 as the optimal dose for experimental infections. This compelling high susceptibility leading to productive infections in Golden Syrian hamsters must be considered as a potential source of SARS-CoV-2 infection for humans that come into close contact with pet hamsters.

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Language(s): eng - English
 Dates: 2022-09-05
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41598-022-19222-4
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 12 Sequence Number: 15069 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322