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  Hippocampal spatio-predictive cognitive maps adaptively guide reward generalization

Garvert, M., Saanum, T., Schulz, E., Schuck, N. W., & Doeller, C. F. (2023). Hippocampal spatio-predictive cognitive maps adaptively guide reward generalization. Nature Neuroscience, 26(4), 615-626. doi:10.1038/s41593-023-01283-x.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-7FE5-5 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-C699-5
Genre: Journal Article

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 Creators:
Garvert, Mona1, 2, 3, Author                 
Saanum, Tankred4, Author
Schulz, Eric4, Author
Schuck, Nicolas W.2, 3, 5, Author
Doeller, Christian F.1, 6, 7, Author                 
Affiliations:
1Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2591710              
2Max Planck Research Group NeuroCode, Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
3Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ou_persistent22              
4Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, ou_persistent22              
5Institute of Psychology, University of Hamburg, Germany, ou_persistent22              
6Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Kavli Institute, Norwegian University of Science and Technology, Norway, ou_persistent22              
7Institute of Psychology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Decision; Hippocampus; Learning algorithms
 Abstract: The brain forms cognitive maps of relational knowledge, an organizing principle thought to underlie our ability to generalize
and make inferences. However, how can a relevant map be selected in situations where a stimulus is embedded in multiple
relational structures? Here, we find that both spatial and predictive cognitive maps influence generalization in a choice task,
where spatial location determines reward magnitude. Mirroring behavior, the hippocampus not only builds a map of spatial
relationships but also encodes the experienced transition structure. As the task progresses, participants’ choices become
more influenced by spatial relationships, reflected in a strengthening of the spatial and a weakening of the predictive map.
This change is driven by orbitofrontal cortex, which represents the degree to which an outcome is consistent with the spatial
rather than the predictive map and updates hippocampal representations accordingly. Taken together, this demonstrates how
hippocampal cognitive maps are used and updated flexibly for inference.

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Language(s): eng - English
 Dates: 2021-10-182023-02-152023-04-032023-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41593-023-01283-x
Other: epub 2023
PMID: 37012381
 Degree: -

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Project name : Independent Max Planck Research Group grant
Grant ID : M.TN.A.BILD0004
Funding program : -
Funding organization : Max Planck Society
Project name : -
Grant ID : EXC2064/1-390727645
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Free and Hanseatic City of Hamburg
Project name : -
Grant ID : ERC-StG-REPLAY-852669
Funding program : -
Funding organization : European Union
Project name : -
Grant ID : ERC-CoG GEOCOG 724836
Funding program : -
Funding organization : European Research Council (ERC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Kavli Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Jebsen Foundation
Project name : -
Grant ID : 223262/F50
Funding program : -
Funding organization : Research Council of Norway—Centre for Neural Computation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits
Project name : -
Grant ID : 197467/F50
Funding program : -
Funding organization : National Infrastructure scheme of the Research Council of Norway—NORBRAIN

Source 1

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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 26 (4) Sequence Number: - Start / End Page: 615 - 626 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931