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  Effects of classic psychedelic drugs on turbulent signatures in brain dynamics

Cruzat, J., Perl, Y. S., Escrichs, A., Vohryzek, J., Timmermann, C., Roseman, L., et al. (2022). Effects of classic psychedelic drugs on turbulent signatures in brain dynamics. Network Neuroscience, 6(4), 1104-1124. doi:10.1162/netn_a_00250.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-9AC7-7 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-EAAB-C
Genre: Journal Article

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 Creators:
Cruzat, Josephine1, 2, 3, Author
Perl, Yonatan Sanz2, Author
Escrichs, Anira2, Author
Vohryzek, Jakub2, 3, Author
Timmermann, Christopher4, Author
Roseman, Leor4, Author
Luppi, Andrea I.5, 6, 7, 8, Author
Ibañez, Agustin1, 9, 10, Author
Nutt, David4, Author
Carhart-Harris, Robin4, 11, Author
Tagliazucchi, Enzo1, 12, Author
Deco, Gustavo2, 13, 14, 15, Author           
Kringelbach, Morten L.3, 16, 17, Author
Affiliations:
1Latin American Brain Health Institute (BrainLat), University Adolfo Ibañez, Santiago, Chile, ou_persistent22              
2Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Centre for Eudaimonia and Human Flourishing, University of Oxford, United Kingdom, ou_persistent22              
4Psychedelic Research Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, United Kingdom, ou_persistent22              
5Division of Anaesthesia, School of Medicine, University of Cambridge, United Kingdom, ou_persistent22              
6Department of Clinical Neuroscience, University of Cambridge, United Kingdom, ou_persistent22              
7Leverhulme Centre for the Future of Intelligence, University of Cambridge, United Kingdom, ou_persistent22              
8The Alan Turing Institute, London, United Kingdom, ou_persistent22              
9National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina, ou_persistent22              
10Global Brain Health Institute (GBHI), Trinity College Dublin, Ireland, ou_persistent22              
11Neuroscape Psychedelics Division, University of California, San Francisco, CA, USA, ou_persistent22              
12Department of Physics, University of Buenos Aires, Argentina, ou_persistent22              
13Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
14Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
15School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
16Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
17Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              

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Free keywords: Psychedelics; Psilocybin; LSD; Turbulence
 Abstract: Psychedelic drugs show promise as safe and effective treatments for neuropsychiatric disorders, yet their mechanisms of action are not fully understood. A fundamental hypothesis is that psychedelics work by dose-dependently changing the functional hierarchy of brain dynamics, but it is unclear whether different psychedelics act similarly. Here, we investigated the changes in the brain’s functional hierarchy associated with two different psychedelics (LSD and psilocybin). Using a novel turbulence framework, we were able to determine the vorticity, that is, the local level of synchronization, that allowed us to extend the standard global time-based measure of metastability to become a local-based measure of both space and time. This framework produced detailed signatures of turbulence-based hierarchical change for each psychedelic drug, revealing consistent and discriminate effects on a higher level network, that is, the default mode network. Overall, our findings directly support a prior hypothesis that psychedelics modulate (i.e., “compress”) the functional hierarchy and provide a quantification of these changes for two different psychedelics. Implications for therapeutic applications of psychedelics are discussed.

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Language(s): eng - English
 Dates: 2021-11-252022-04-062022-10-01
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1162/netn_a_00250
 Degree: -

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Project name : -
Grant ID : HBP SGA3 945539; 101017716
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : CW2680521
Funding program : -
Funding organization : Takeda
Project name : -
Grant ID : 1210195; 1210176
Funding program : -
Funding organization : ANID/FONDECYT
Project name : -
Grant ID : 2017-1820
Funding program : -
Funding organization : Proyectos de Investigación Científica y Tecnológica (PICT)
Project name : -
Grant ID : GBHI ALZ UK-20-639295; SG-20-725707
Funding program : -
Funding organization : Alzheimer’s Association
Project name : -
Grant ID : R01 AG057234
Funding program : -
Funding organization : National Institutes of Aging (NIA)
Project name : -
Grant ID : PICT-2019-02294; PICT-2018-03103
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : PID2019-105772GB-I00 MCIU AEI
Funding program : -
Funding organization : Spanish Ministry of Science, Innovation and Universities (MCIU)
Project name : -
Grant ID : 2017 SGR 1545
Funding program : -
Funding organization : SGR Research Support Group
Project name : -
Grant ID : 860563
Funding program : -
Funding organization : euSNN European School of Network Neuroscience
Project name : -
Grant ID : 001-P-001682
Funding program : -
Funding organization : CECH The Emerging Human Brain Cluster
Project name : -
Grant ID : 201725.33
Funding program : -
Funding organization : Brain-Connects
Project name : -
Grant ID : PCI2018-092891
Funding program : -
Funding organization : State Research Agency (AEI)
Project name : -
Grant ID : DNRF117
Funding program : -
Funding organization : Danish National Research Foundation (DNRF)

Source 1

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Title: Network Neuroscience
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, MA : MIT Press
Pages: - Volume / Issue: 6 (4) Sequence Number: - Start / End Page: 1104 - 1124 Identifier: ISSN: 2472-1751
CoNE: https://pure.mpg.de/cone/journals/resource/2472-1751