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  A comparative perspective on the cerebello-cerebral system and its link to cognition

Magielse, N., Heuer, K., Toro, R., Schutter, D. J. L. G., & Valk, S. L. (2023). A comparative perspective on the cerebello-cerebral system and its link to cognition. The Cerebellum, 22(6), 1293-1307. doi:10.1007/s12311-022-01495-0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-9ADF-D Version Permalink: https://hdl.handle.net/21.11116/0000-000D-F511-B
Genre: Journal Article

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 Creators:
Magielse, Neville1, 2, 3, Author           
Heuer, Katja4, 5, Author           
Toro, Roberto4, Author
Schutter, Dennis J. L. G.6, Author
Valk, Sofie L.1, 2, 3, Author                 
Affiliations:
1Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
2Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
3Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
4Unité de Neuroanatomie Appliquée et Théorique, Institute Pasteur, Université Paris Cité, France, ou_persistent22              
5Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
6Department of Experimental Psychology, Helmholtz Institute, Utrecht University, the Netherlands, ou_persistent22              

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Free keywords: Cerebellum; Cerebral cortex; Cognition; Evolution; Human; Primates
 Abstract: The longstanding idea that the cerebral cortex is the main neural correlate of human cognition can be elaborated by comparative analyses along the vertebrate phylogenetic tree that support the view that the cerebello-cerebral system is suited to support non-motor functions more generally. In humans, diverse accounts have illustrated cerebellar involvement in cognitive functions. Although the neocortex, and its transmodal association cortices such as the prefrontal cortex, have become disproportionately large over primate evolution specifically, human neocortical volume does not appear to be exceptional relative to the variability within primates. Rather, several lines of evidence indicate that the exceptional volumetric increase of the lateral cerebellum in conjunction with its connectivity with the cerebral cortical system may be linked to non-motor functions and mental operation in primates. This idea is supported by diverging cerebello-cerebral adaptations that potentially coevolve with cognitive abilities across other vertebrates such as dolphins, parrots, and elephants. Modular adaptations upon the vertebrate cerebello-cerebral system may thus help better understand the neuroevolutionary trajectory of the primate brain and its relation to cognition in humans. Lateral cerebellar lobules crura I-II and their reciprocal connections to the cerebral cortical association areas appear to have substantially expanded in great apes, and humans. This, along with the notable increase in the ventral portions of the dentate nucleus and a shift to increased relative prefrontal-cerebellar connectivity, suggests that modular cerebellar adaptations support cognitive functions in humans. In sum, we show how comparative neuroscience provides new avenues to broaden our understanding of cerebellar and cerebello-cerebral functions in the context of cognition.

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Language(s): eng - English
 Dates: 2022-11-112022-11-232023-12
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s12311-022-01495-0
Other: epub 2022
PMID: 36417091
 Degree: -

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Project name : -
Grant ID : No101033485
Funding program : Horizon 2020
Funding organization : European Union
Project name : Helmholtz Association’s Initiative and Networking Fund
Grant ID : InterLabs-0015
Funding program : -
Funding organization : Helmholtz International
Project name : -
Grant ID : -
Funding program : -
Funding organization : Projekt DEAL
Project name : NeuroWebLab; DMOBE
Grant ID : ANR-19-DATA-0025; ANR-21-CE45-0016
Funding program : -
Funding organization : French Agence Nationale de la Recherche (ANR)
Project name : -
Grant ID : VI.C.181.005
Funding program : -
Funding organization : Dutch Research Council (NWO)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Canada First Research Excellence Fund (CFREF)

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Title: The Cerebellum
Source Genre: Journal
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Publ. Info: New York, NY : Springer
Pages: - Volume / Issue: 22 (6) Sequence Number: - Start / End Page: 1293 - 1307 Identifier: ISSN: 1473-4222
CoNE: https://pure.mpg.de/cone/journals/resource/1473-4222