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  Measuring inhomogeneous MT (ihMT) in human brain by multi-parameter mapping (MPM)

Helms, G., Vaculciakova, L., Pine, K., Möller, H. E., & Weiskopf, N. (2021). Measuring inhomogeneous MT (ihMT) in human brain by multi-parameter mapping (MPM). In Proceedings of the 2021 ISMRM & ISMRT Annual Meeting and Exhibition.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-9E41-A Version Permalink: https://hdl.handle.net/21.11116/0000-000F-6514-9
Genre: Meeting Abstract

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 Creators:
Helms, Gunther1, Author           
Vaculciakova, Lenka1, Author                 
Pine, Kerrin1, Author                 
Möller, Harald E.2, Author                 
Weiskopf, Nikolaus1, Author                 
Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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 Abstract: Inhomogenous Magnetization Transfer (ihMT), the differential response to irradiation at single and dual frequency offsets, is sensitive to myelination. Quantification of ihMT in terms of MT saturation (MTsat), the percent reduction of Mz, corrects for underlying T1 and B1+ and allows comparing different implementations to optimize multi-parameter mapping (MPM) protocols. ihMTsat in white matter is roughly one twentieth of MTsat, merely 0.2 p.u. at 5kHz and 100% SAR at 3T. Noise propagation demands acquisition at 1.5mm resolution, large-array coils, and smaller offsets than suggested previously. Inverse MT ratios are highly correlated to ihMTs but obscure the true effect size.

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 Dates: 2021-04-30
 Publication Status: Published online
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Title: 2021 ISMRM & ISMRT Annual Meeting and Exhibition
Place of Event: online
Start-/End Date: 2021-05-15 - 2021-05-20

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Title: Proceedings of the 2021 ISMRM & ISMRT Annual Meeting and Exhibition
Source Genre: Proceedings
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Pages: - Volume / Issue: 29 Sequence Number: - Start / End Page: - Identifier: -