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  RGM is a repulsive guidance molecule for retinal axons

Monnier, P., Sierra, A., Macchi, P., Deitinghoff, L., Andersen, J., Mann, M., et al. (2002). RGM is a repulsive guidance molecule for retinal axons. Nature, 419(6905), 392-395. doi:10.1038/nature01041.

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 Creators:
Monnier, PP, Author
Sierra, A, Author
Macchi, P1, Author                 
Deitinghoff, L, Author
Andersen, JS, Author
Mann, M, Author
Flad, M, Author
Hornberger, MR, Author           
Stahl, B, Author
Bonhoeffer, F1, Author           
Mueller, BK, Author                 
Affiliations:
1Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3384683              

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 Abstract: Axons rely on guidance cues to reach remote targets during nervous system development. A well-studied model system for axon guidance is the retinotectal projection. The retina can be divided into halves; the nasal half, next to the nose, and the temporal half. A subset of retinal axons, those from the temporal half, is guided by repulsive cues expressed in a graded fashion in the optic tectum, part of the midbrain. Here we report the cloning and functional characterization of a membrane-associated glycoprotein, which we call RGM (repulsive guidance molecule). This molecule shares no sequence homology with known guidance cues, and its messenger RNA is distributed in a gradient with increasing concentration from the anterior to posterior pole of the embryonic tectum. Recombinant RGM at low nanomolar concentration induces collapse of temporal but not of nasal growth cones and guides temporal retinal axons in vitro, demonstrating its repulsive and axon-specific guiding activity.

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 Dates: 2002-09
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/nature01041
PMID: 12353034
 Degree: -

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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 419 (6905) Sequence Number: - Start / End Page: 392 - 395 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238