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  Novel spiroannulated 3-benzofuranones: Synthesis and inhibition of the human peptidyl prolyl cis/trans isomerase Pin1

Braun, M., Hessamian-Alineja, A., Féaux de Lacroix, B., Hernandez Alvarez, B., & Fischer, G. (2008). Novel spiroannulated 3-benzofuranones: Synthesis and inhibition of the human peptidyl prolyl cis/trans isomerase Pin1. Molecules, 13(4), 995-1003. doi:10.3390/molecules13040995.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-A768-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-C9E8-D
Genre: Journal Article

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Braun, M, Author
Hessamian-Alineja, A, Author
Féaux de Lacroix, B, Author
Hernandez Alvarez, B1, Author                 
Fischer, G, Author
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1External Organizations, ou_persistent22              

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 Abstract: The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been made accessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclic benzofuranones 2 and 3, respectively. A four-step synthesis to spirocompound 4 is described. The novel spirocyclic benzofuranones display modest to no inhibition of the human peptidyl prolyl cis/trans isomerase Pin1.

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 Dates: 2008-04
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.3390/molecules13040995
PMID: 18463601
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Title: Molecules
Source Genre: Journal
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Publ. Info: Basel : MDPI
Pages: - Volume / Issue: 13 (4) Sequence Number: - Start / End Page: 995 - 1003 Identifier: ISSN: 1420-3049
CoNE: https://pure.mpg.de/cone/journals/resource/954925623244