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  Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M. E., Aguzzi, A., Ajami, B., et al. (2022). Microglia states and nomenclature: A field at its crossroads. Neuron, 110(21), 3458-3483. doi:10.1016/j.neuron.2022.10.020.

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Paolicelli, R. C., Author
Sierra, A., Author
Stevens, B., Author
Tremblay, M. E., Author
Aguzzi, A., Author
Ajami, B., Author
Amit, I., Author
Audinat, E., Author
Bechmann, I., Author
Bennett, M., Author
Bennett, F., Author
Bessis, A., Author
Biber, K., Author
Bilbo, S., Author
Blurton-Jones, M., Author
Boddeke, E., Author
Brites, D., Author
Brone, B., Author
Brown, G. C., Author
Butovsky, O., Author
Carson, M. J., AuthorCastellano, B., AuthorColonna, M., AuthorCowley, S. A., AuthorCunningham, C., AuthorDavalos, D., AuthorDe Jager, P. L., Authorde Strooper, B., AuthorDenes, A., AuthorEggen, B. J. L., AuthorEyo, U., AuthorGalea, E., AuthorGarel, S., AuthorGinhoux, F., AuthorGlass, C. K., AuthorGokce, O., AuthorGomez-Nicola, D., AuthorGonzalez, B., AuthorGordon, S., AuthorGraeber, M. B., AuthorGreenhalgh, A. D., AuthorGressens, P., AuthorGreter, M., AuthorGutmann, D. H., AuthorHaass, C., AuthorHeneka, M. T., AuthorHeppner, F. L., AuthorHong, S., AuthorHume, D. A., AuthorJung, S., AuthorKettenmann, H., AuthorKipnis, J., AuthorKoyama, R., AuthorLemke, G., AuthorLynch, M., AuthorMajewska, A., AuthorMalcangio, M., AuthorMalm, T., AuthorMancuso, R., AuthorMasuda, T., AuthorMatteoli, M., AuthorMcColl, B. W., AuthorMiron, V. E., AuthorMolofsky, A. V., AuthorMonje, M., AuthorMracsko, E., AuthorNadjar, A., AuthorNeher, J. J., AuthorNeniskyte, U., AuthorNeumann, H., AuthorNoda, M., AuthorPeng, B., AuthorPeri, F., AuthorPerry, V. H., AuthorPopovich, P. G., AuthorPridans, C., AuthorPriller, J., AuthorPrinz, M., AuthorRagozzino, D., AuthorRansohoff, R. M., AuthorSalter, M. W., AuthorSchaefer, A.1, Author           Schafer, D. P., AuthorSchwartz, M., AuthorSimons, M., AuthorSmith, C. J., AuthorStreit, W. J., AuthorTay, T. L., AuthorTsai, L. H., AuthorVerkhratsky, A., Authorvon Bernhardi, R., AuthorWake, H., AuthorWittamer, V., AuthorWolf, S. A., AuthorWu, L. J., AuthorWyss-Coray, T., Author more..
Affiliations:
1Department Schaefer - Neurobiology of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_3393997              

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Free keywords: *Microglia
 Abstract: Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.

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 Dates: 2022-11-022022
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: Other: 36327895
DOI: 10.1016/j.neuron.2022.10.020
ISSN: 1097-4199 (Electronic)0896-6273 (Linking)
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Title: Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 110 (21) Sequence Number: - Start / End Page: 3458 - 3483 Identifier: -