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  Resilience integrates concepts in aging research

Promislow, D., Anderson, R. M., Scheffer, M., Crespi, B., DeGregori, J., Harris, K., et al. (2022). Resilience integrates concepts in aging research. iScience, 25(5), 104199. doi:10.1016/j.isci.2022.104199.

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 Creators:
Promislow, D., Author
Anderson, R. M., Author
Scheffer, M., Author
Crespi, B., Author
DeGregori, J., Author
Harris, K., Author
Horowitz, B. N., Author
Levine, M. E., Author
Riolo, M. A., Author
Schneider, D. S., Author
Spencer, S. L., Author
Valenzano, D. R.1, Author           
Hochberg, M. E., Author
Affiliations:
1Valenzano – Evolutionary and Experimental Biology of Ageing, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942297              

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Free keywords: Biological sciences Cell biology Evolutionary biology Health sciences Molecular biology
 Abstract: Aging research is unparalleled in the breadth of disciplines it encompasses, from evolutionary studies examining the forces that shape aging to molecular studies uncovering the underlying mechanisms of age-related functional decline. Despite a common focus to advance our understanding of aging, these disciplines have proceeded along distinct paths with little cross-talk. We propose that the concept of resilience can bridge this gap. Resilience describes the ability of a system to respond to perturbations by returning to its original state. Although resilience has been applied in a few individual disciplines in aging research such as frailty and cognitive decline, it has not been explored as a unifying conceptual framework that is able to connect distinct research fields. We argue that because a resilience-based framework can cross broad physiological levels and time scales it can provide the missing links that connect these diverse disciplines. The resulting framework will facilitate predictive modeling and validation and influence targets and directions in research on the biology of aging.

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 Dates: 2022-04-062022-04-06
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: Other: 35494229
DOI: 10.1016/j.isci.2022.104199
ISSN: 2589-0042 (Electronic)2589-0042 (Linking)
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Title: iScience
Source Genre: Journal
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Pages: - Volume / Issue: 25 (5) Sequence Number: - Start / End Page: 104199 Identifier: -