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  Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility

Zambarda, C., González, C. P., Schoenit, A., Veits, N., Schimmer, C., Jung, R., et al. (2022). Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility. European Journal of Cell Biology: EJCB, 101(4): 151274, pp. 1-12. doi:10.1016/j.ejcb.2022.151274.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-B63A-7 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-B63B-6
Genre: Journal Article

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 Creators:
Zambarda, Chiara1, Author           
González, Carlos Pérez, Author
Schoenit, Andreas1, Author           
Veits, Nisha2, Author           
Schimmer, Clara2, Author           
Jung, Raimund2, Author           
Ollech, Dirk1, Author           
Christian, Joel1, Author           
Roca-Cusachs, Pere, Author
Trepat, Xavier, Author
Cavalcanti-Adam, Elisabetta Ada1, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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Free keywords: Collective contractility; Actomyosin; EGF; Traction forces; Adherens junctions; Micropatterning
 Abstract: Several factors present in the extracellular environment regulate epithelial cell adhesion and dynamics. Among them, growth factors such as EGF, upon binding to their receptors at the cell surface, get internalized and directly activate the acto-myosin machinery. In this study we present the effects of EGF on the contractility of epithelial cancer cell colonies in confined geometry of different sizes. We show that the extent to which EGF triggers contractility scales with the cluster size and thus the number of cells. Moreover, the collective contractility results in a radial distribution of traction forces, which are dependent on integrin β1 peripheral adhesions and transmitted to neighboring cells through adherens junctions. Taken together, EGF-induced contractility acts on the mechanical crosstalk and linkage between the cell-cell and cell-matrix compartments, regulating collective responses.

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Language(s): eng - English
 Dates: 2022-08-082021-12-292022-09-082022-09-172022-09
 Publication Status: Issued
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.ejcb.2022.151274
 Degree: -

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Title: European Journal of Cell Biology : EJCB
  Other : Eur. J. Cell Biol.
Source Genre: Journal
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Publ. Info: Stuttgart : Wissenschaftliche Verlagsgesellschaft.
Pages: - Volume / Issue: 101 (4) Sequence Number: 151274 Start / End Page: 1 - 12 Identifier: ISSN: 0070-2463
CoNE: https://pure.mpg.de/cone/journals/resource/954925486755