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  Sperm navigation along helical paths in 3D chemoattractant landscapes

Jikeli, J. F., Alvarez, L., Friedrich, B. M., Wilson, L. G., Pascal, R., Colin, R., et al. (2015). Sperm navigation along helical paths in 3D chemoattractant landscapes. NATURE COMMUNICATIONS, 6: 7985. doi:10.1038/ncomms8985.

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 Urheber:
Jikeli, Jan F.1, Autor
Alvarez, Luis1, Autor
Friedrich, Benjamin M.1, Autor
Wilson, Laurence G.1, Autor
Pascal, Rene1, Autor
Colin, Rémy2, Autor                 
Pichlo, Magdalena1, Autor
Rennhack, Andreas1, Autor
Brenker, Christoph1, Autor
Kaupp, U. Benjamin1, Autor
Affiliations:
1external, ou_persistent22              
2Department of Systems and Synthetic Microbiology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, ou_3266288              

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 Zusammenfassung: Sperm require a sense of direction to locate the egg for fertilization. They follow gradients of chemical and physical cues provided by the egg or the oviduct. However, the principles underlying three-dimensional (3D) navigation in chemical landscapes are unknown. Here using holographic microscopy and optochemical techniques, we track sea urchin sperm navigating in 3D chemoattractant gradients. Sperm sense gradients on two timescales, which produces two different steering responses. A periodic component, resulting from the helical swimming, gradually aligns the helix towards the gradient. When incremental path corrections fail and sperm get off course, a sharp turning manoeuvre puts sperm back on track. Turning results from an 'off' Ca2+ response signifying a chemoattractant stimulation decrease and, thereby, a drop in cyclic GMP concentration and membrane voltage. These findings highlight the computational sophistication by which sperm sample gradients for deterministic klinotaxis. We provide a conceptual and technical framework for studying microswimmers in 3D chemical landscapes.

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 Datum: 2015
 Publikationsstatus: Online veröffentlicht
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 Identifikatoren: ISI: 000360347200003
DOI: 10.1038/ncomms8985
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Titel: NATURE COMMUNICATIONS
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 6 Artikelnummer: 7985 Start- / Endseite: - Identifikator: ISSN: 2041-1723