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  Distinct genetic code expansion strategies for selenocysteine and pyrrolysine are reflected in different aminoacyl-tRNA formation systems

Yuan, J., O'Donoghue, P., Ambrogelly, A., Gundllapalli, S., Sherrer, R. L., Palioura, S., et al. (2010). Distinct genetic code expansion strategies for selenocysteine and pyrrolysine are reflected in different aminoacyl-tRNA formation systems. FEBS LETTERS, 584(2), 342-349. doi:10.1016/j.febslet.2009.11.005.

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 Creators:
Yuan, Jing1, Author                 
O'Donoghue, Patrick2, Author
Ambrogelly, Alex2, Author
Gundllapalli, Sarath2, Author
Sherrer, R. Lynn2, Author
Palioura, Sotiria2, Author
Simonovic, Miljan2, Author
Soell, Dieter2, Author
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1Department of Molecular Biophysics and Biochemistry, Yale University, USA, ou_persistent22              
2external, ou_persistent22              

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 Abstract: Selenocysteine and pyrrolysine, known as the 21st and 22nd amino acids, are directly inserted into growing polypeptides during translation. Selenocysteine is synthesized via a tRNA-dependent pathway and decodes UGA (opal) codons. The incorporation of selenocysteine requires the concerted action of specific RNA and protein elements. In contrast, pyrrolysine is ligated directly to tRNA(Pyl) and inserted into proteins in response to UAG (amber) codons without the need for complex re-coding machinery. Here we review the latest updates on the structure and mechanisms of molecules involved in Sec-tRNA(Sec) and Pyl-tRNA(Pyl) formation as well as the distribution of the Pyl-decoding trait. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

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 Dates: 2010
 Publication Status: Issued
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Title: FEBS LETTERS
Source Genre: Journal
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Pages: - Volume / Issue: 584 (2) Sequence Number: - Start / End Page: 342 - 349 Identifier: ISSN: 0014-5793