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  A binocular synaptic network supports interocular response alignment in visual cortical neurons

Scholl, B., Tepohl, C., Ryan, M. A., Thomas, C., Kamasawa, N., & Fitzpatrick, D. (2022). A binocular synaptic network supports interocular response alignment in visual cortical neurons. Neuron, 1-12.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-FC03-6 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-FC04-5
Genre: Journal Article
Alternative Title : Neuron

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 Creators:
Scholl, Benjamin1, Author
Tepohl, Clara1, Author
Ryan, Melissa A.1, Author
Thomas, Connon1, Author
Kamasawa, Naomi1, Author
Fitzpatrick, David1, Author
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1Max Planck Florida Institute for Neuroscience, Max Planck Society, One Max Planck Way, Jupiter FL 33458, USA, ou_1950288              

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 Abstract: In visual cortex, signals from the two eyes merge to form a coherent binocular representation. Here we investigate the synaptic interactions underlying the binocular representation of stimulus orientation in ferret visual cortex with in vivo calcium imaging of layer 2/3 neurons and their dendritic spines. Individual neurons with aligned somatic responses received a mixture of monocular and binocular synaptic inputs. Surprisingly, monocular pathways alone could not account for somatic alignment because ipsilateral monocular inputs poorly matched somatic preference. Binocular inputs exhibited different degrees of interocular alignment, and those with a high degree of alignment (congruent) had greater selectivity and somatic specificity. While congruent inputs were similar to others in measures of strength, simulations show that the number of active congruent inputs predicts aligned somatic output. Our study suggests that coherent binocular responses derive from connectivity biases that support functional amplification of aligned signals within a heterogeneous binocular intracortical network.

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 Dates: 2022
 Publication Status: Issued
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Title: Neuron
Source Genre: Journal
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 1 - 12 Identifier: -