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  A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

Inagaki, H. K., Chen, S., Ridder, M. C., Sah, P., Li, N., Yang, Z., et al. (2022). A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement. Cell. Retrieved from https://www.sciencedirect.com/science/article/pii/S0092867422001465.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-FBDB-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-FBDC-3
Genre: Journal Article
Alternative Title : Cell

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 Creators:
Inagaki, Hidehiko K.1, Author
Chen, Susu, Author
Ridder, Margreet C., Author
Sah, Pankaj, Author
Li, Nuo, Author
Yang, Zidan1, Author
Hasanbegovic, Hana, Author
Gao, Zhenyu, Author
Gerfen, Charles R., Author
Svoboda, Karel, Author
Affiliations:
1Max Planck Florida Institute for Neuroscience, Max Planck Society, One Max Planck Way, Jupiter FL 33458, USA, ou_1950288              

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Free keywords: optogenetics, dimensionality reduction, licking, midbrain locomotor region, motor control, Neuropixels, short-term memory, silicon probe, spikes, state space
 Abstract: Motor behaviors are often planned long before execution but only released after specific sensory events. Planning and execution are each associated with distinct patterns of motor cortex activity. Key questions are how these dynamic activity patterns are generated and how they relate to behavior. Here, we investigate the multi-regional neural circuits that link an auditory “Go cue” and the transition from planning to execution of directional licking. Ascending glutamatergic neurons in the midbrain reticular and pedunculopontine nuclei show short latency and phasic changes in spike rate that are selective for the Go cue. This signal is transmitted via the thalamus to the motor cortex, where it triggers a rapid reorganization of motor cortex state from planning-related activity to a motor command, which in turn drives appropriate movement. Our studies show how midbrain can control cortical dynamics via the thalamus for rapid and precise motor behavior.

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 Dates: 2022
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: URI: https://www.sciencedirect.com/science/article/pii/S0092867422001465
URI: https://www.cell.com/article/S0092867422001465/pdf
URI: https://www.sciencedirect.com/science/article/pii/S0092867422001465?via%3Dihub
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Title: Cell
  Alternative Title : Cell
Source Genre: Journal
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISBN: 0092-8674