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Zusammenfassung:
To understand cell signalling during development, we need to know how whole signalling networks — not just their individual components — are regulated. Two new studies highlight this point.
In simplistic terms, living organisms can be broken down into modules — distinct ensembles of interacting elements that are used in a combinatorial fashion. Modules occur at all levels of biological organization and can encompass physical clusters (such as ribosomes and other multimolecule cellular machines) as well as processes (such as cell-to-cell signalling pathways). One kind of module is the 'synexpression group', a genetic network with an important role in animal development. Member genes of a synexpression group not only function in a common pathway, but are also expressed in the same tight temporal and spatial pattern.
