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Zusammenfassung:
The free-living nematode Pristionchus pacificus has been described as a satellite organism for functional comparative studies in developmental biology. Like the model organism Caenorhabditis elegans, P. pacificus is easily culturable in the laboratory. P. pacificus, is a hermaphroditic species, with a 4-day life cycle, but unlike most nematodes which pass through 4 juvenile stages during their development, P. pacificus has only three juvenile stages. The combination of cellular, genetic and molecular studies has made P. pacificus a perfect model system for studying evolutionary developmental biology. One process that has been studied in detail is the development of the vulva. Genetic and molecular studies have revealed that the function of several genes involved in vulva development differs between P. pacificus and C. elegans. Here, we review our macroevolutionary comparison between P. pacificus and C. elegans and provide data on the biogeography of the genus Pristionchus. The genus has a world-wide distribution with strains from Northern America, Europe, Madagascar and New Zealand. Sequence analyses of the rDNA internal transcribed spacer (ITS) region and mating experiments revealed that the 12 hermaphroditic strains studied, belong to three different species. Strains isolated from Northern America belong predominantly to Pristionchus pacificus, whereas the european strains are members of Pristionchus maupasi and a new species yet to be described.
