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  Dynamic localization cycle of the cell division regulator MinE in Escherichia coli

Hale, C., Meinhardt, H., & de Boer, P. (2001). Dynamic localization cycle of the cell division regulator MinE in Escherichia coli. EMBO Journal, 20(7), 1563-1572. doi:10.1093/emboj/20.7.1563.

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 Urheber:
Hale, CA, Autor
Meinhardt, H1, Autor                 
de Boer, PA, Autor
Affiliations:
1Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375786              

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 Zusammenfassung: The MinC protein directs placement of the division septum to the middle of Escherichia coli cells by blocking assembly of the division apparatus at other sites. MinD and MinE regulate MinC activity by modulating its cellular location in a unique fashion. MinD recruits MinC to the membrane, and MinE induces MinC/MinD to oscillate rapidly between the membrane of opposite cell halves. Using fixed cells, we previously found that a MinE-green fluorescent protein fusion accumulated in an annular structure at or near the midcell, as well as along the membrane on only one side of the ring. Here we show that in living cells, MinE undergoes a rapid localization cycle that appears coupled to MinD oscillation. The results show that MinE is not a fixed marker for septal ring assembly. Rather, they support a model in which MinE stimulates the removal of MinD from the membrane in a wave-like fashion. These waves run from a midcell position towards the poles in an alternating sequence such that the time-averaged concentration of division inhibitor is lowest at midcell.

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 Datum: 2001-04
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Identifikatoren: DOI: 10.1093/emboj/20.7.1563
PMID: 11285221
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Titel: EMBO Journal
  Andere : EMBO J.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Nature Publishing Group
Seiten: - Band / Heft: 20 (7) Artikelnummer: - Start- / Endseite: 1563 - 1572 Identifikator: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061