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  Pattern formation by local self-activation and lateral inhibition

Meinhardt, H., & Gierer, A. (2000). Pattern formation by local self-activation and lateral inhibition. Bioessays, 22(8), 753-760. doi:10.1002/1521-1878(200008)22:8<753:AID-BIES9>3.0.CO;2-Z.

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 Urheber:
Meinhardt, H1, Autor                 
Gierer, A2, Autor           
Affiliations:
1Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375786              
2Department Molecular Biology Gierer, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3404872              

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 Zusammenfassung: In 1972, we proposed a theory of biological pattern formation in which concentration maxima of pattern forming substances are generated through local self-enhancement in conjunction with long range inhibition. Since then, much evidence in various developmental systems has confirmed the importance of autocatalytic feedback loops combined with inhibitory interaction. Examples are found in the formation of embryonal organizing regions, in segmentation, in the polarization of individual cells, and in gene activation. By computer simulations, we have shown that the theory accounts for much of the regulatory phenomena observed, including signalling to regenerate removed parts. These self-regulatory features contribute to making development robust and error-tolerant. Furthermore, the resulting pattern is, to a large extent, independent of the details provided by initial conditions and inducing signals.

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 Datum: 2000-08
 Publikationsstatus: Erschienen
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Titel: Bioessays
  Andere : Bioessays
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Cambridge, UK : Co. of Biologists
Seiten: - Band / Heft: 22 (8) Artikelnummer: - Start- / Endseite: 753 - 760 Identifikator: ISSN: 0265-9247
CoNE: https://pure.mpg.de/cone/journals/resource/954925499109