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  Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice

Schepanski, S., Chini, M., Sternemann, V., Urbschat, C., Thiele, K., Sun, T., et al. (2022). Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice. Nature Communications, 13(1): 4571. doi:10.1038/s41467-022-32230-2.

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 Urheber:
Schepanski, Steven, Autor
Chini, Mattia, Autor
Sternemann, Veronika, Autor
Urbschat, Christopher, Autor
Thiele, Kristin, Autor
Sun, Ting1, Autor           
Zhao, Yu, Autor
Poburski, Mareike, Autor
Woestemeier, Anna, Autor
Thieme, Marie-Theres, Autor
Zazara, Dimitra E., Autor
Alawi, Malik, Autor
Fischer, Nicole, Autor
Heeren, Joerg, Autor
Vladimirov, Nikita, Autor
Woehler, Andrew, Autor
Puelles, Victor G., Autor
Bonn, Stefan, Autor
Gagliani, Nicola, Autor
Hanganu-Opatz, Ileana L., Autor
Arck, Petra C., Autor mehr..
Affiliations:
1Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350301              

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 Zusammenfassung: Life-long brain function and mental health are critically determined by developmental processes occurring before birth. During mammalian pregnancy, maternal cells are transferred to the fetus. They are referred to as maternal microchimeric cells (MMc). Among other organs, MMc seed into the fetal brain, where their function is unknown. Here, we show that, in the offspring’s developing brain in mice, MMc express a unique signature of sensome markers, control microglia homeostasis and prevent excessive presynaptic elimination. Further, MMc facilitate the oscillatory entrainment of developing prefrontal-hippocampal circuits and support the maturation of behavioral abilities. Our findings highlight that MMc are not a mere placental leak out, but rather a functional mechanism that shapes optimal conditions for healthy brain function later in life.

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Sprache(n): eng - English
 Datum: 2022-08-05
 Publikationsstatus: Online veröffentlicht
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/s41467-022-32230-2
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Projektname : We thank Agnes Wieczorek, Thomas Andreas, Annette Marquardt, Peggy Putthoff, Achim Dahlmann, Kristin Titze and Sandra Ehret for technical assistance. We thank Urte Matschl for support with Luminex measurements. The support from the staff members of the institutional core facilities (Microscopy Imaging Facility, FACS Sorting Core Unit, and Animal Housing Facility) and the NGS division of the Heinrich Pette Institute Hamburg (Dr. Daniela Indenbirken) is also appreciated. We thank Prof. Judith Eckert for support in yolk sac isolations. We thank Prof. Dr. Carlos A. Guzmán for providing B6.129-Rag2tm1CgnIl2rgtm1Cgn mice, Dr. Jan-Eric Turner for providing Balb/c-Rag2−/−IL-2rγc−/− mice, and Dr. Nicola Wanner for providing C57BL/6-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J mice. This work was supported by German Research Foundation (HA 4466/10-1, HA4466/12-1, HA4466/20-1: 178316478 CRC 936 B5 to I.L.H.-O.; KFO296: AR232/25-2, FOR5068: AR232/29-1 to P.C.A.; CRC1192 to V.G.P.); the Federal Ministry of Education and Research (BMBF: eMed Consortia Fibromap to V.G.P); the European Research Council (ERC-2015-CoG 681577, MSCA-ITN-H2020-860563 to I.L.H.-O.); and State Research Funding, Authority for Science, Research and Equality, Hamburg, Germany (LFF-FV73 and LFF-FV76 to P.C.A. and I.L.H.-O. respectively). S.S. received a fellowship from the Forschungsförderungsfond of the University Medical Center Hamburg-Eppendorf.
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Titel: Nature Communications
  Kurztitel : Nat. Commun.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: London : Nature Publishing Group
Seiten: - Band / Heft: 13 (1) Artikelnummer: 4571 Start- / Endseite: - Identifikator: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723