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  Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice

Schepanski, S., Chini, M., Sternemann, V., Urbschat, C., Thiele, K., Sun, T., et al. (2022). Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice. Nature Communications, 13(1): 4571. doi:10.1038/s41467-022-32230-2.

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 Creators:
Schepanski, Steven, Author
Chini, Mattia, Author
Sternemann, Veronika, Author
Urbschat, Christopher, Author
Thiele, Kristin, Author
Sun, Ting1, Author           
Zhao, Yu, Author
Poburski, Mareike, Author
Woestemeier, Anna, Author
Thieme, Marie-Theres, Author
Zazara, Dimitra E., Author
Alawi, Malik, Author
Fischer, Nicole, Author
Heeren, Joerg, Author
Vladimirov, Nikita, Author
Woehler, Andrew, Author
Puelles, Victor G., Author
Bonn, Stefan, Author
Gagliani, Nicola, Author
Hanganu-Opatz, Ileana L., Author
Arck, Petra C., Author more..
Affiliations:
1Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350301              

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 Abstract: Life-long brain function and mental health are critically determined by developmental processes occurring before birth. During mammalian pregnancy, maternal cells are transferred to the fetus. They are referred to as maternal microchimeric cells (MMc). Among other organs, MMc seed into the fetal brain, where their function is unknown. Here, we show that, in the offspring’s developing brain in mice, MMc express a unique signature of sensome markers, control microglia homeostasis and prevent excessive presynaptic elimination. Further, MMc facilitate the oscillatory entrainment of developing prefrontal-hippocampal circuits and support the maturation of behavioral abilities. Our findings highlight that MMc are not a mere placental leak out, but rather a functional mechanism that shapes optimal conditions for healthy brain function later in life.

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Language(s): eng - English
 Dates: 2022-08-05
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-022-32230-2
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Project name : We thank Agnes Wieczorek, Thomas Andreas, Annette Marquardt, Peggy Putthoff, Achim Dahlmann, Kristin Titze and Sandra Ehret for technical assistance. We thank Urte Matschl for support with Luminex measurements. The support from the staff members of the institutional core facilities (Microscopy Imaging Facility, FACS Sorting Core Unit, and Animal Housing Facility) and the NGS division of the Heinrich Pette Institute Hamburg (Dr. Daniela Indenbirken) is also appreciated. We thank Prof. Judith Eckert for support in yolk sac isolations. We thank Prof. Dr. Carlos A. Guzmán for providing B6.129-Rag2tm1CgnIl2rgtm1Cgn mice, Dr. Jan-Eric Turner for providing Balb/c-Rag2−/−IL-2rγc−/− mice, and Dr. Nicola Wanner for providing C57BL/6-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J mice. This work was supported by German Research Foundation (HA 4466/10-1, HA4466/12-1, HA4466/20-1: 178316478 CRC 936 B5 to I.L.H.-O.; KFO296: AR232/25-2, FOR5068: AR232/29-1 to P.C.A.; CRC1192 to V.G.P.); the Federal Ministry of Education and Research (BMBF: eMed Consortia Fibromap to V.G.P); the European Research Council (ERC-2015-CoG 681577, MSCA-ITN-H2020-860563 to I.L.H.-O.); and State Research Funding, Authority for Science, Research and Equality, Hamburg, Germany (LFF-FV73 and LFF-FV76 to P.C.A. and I.L.H.-O. respectively). S.S. received a fellowship from the Forschungsförderungsfond of the University Medical Center Hamburg-Eppendorf.
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
 Creator(s):
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 13 (1) Sequence Number: 4571 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723