hide
Free keywords:
-
Abstract:
Cyclin proteins act as regulatory subunits in complexes with the p34cdc2 protein kinase. The kinase activities of such complexes are thought to govern progression through the eukaryotic cell cycle. Work in a variety of organisms has suggested that different cyclin/p34cdc2 complexes act at distinct control points during the cell cycle. In Saccharomyces cerevisiae, progression through G1 phase into S phase (START) is controlled by complexes containing the cyclin proteins encoded by the genes CLN1, CLN2, and CLN3 (Richardson et al. 1989). Various cyclin proteins likely to be involved in the G1/S transition have also been identified recently in cells of higher eukaryotes (Leopold and O'Farrell 1991; Matsushime et al. 1991; Motokura et al. 1991; Xiong et al. 1991). The G2/M transition, on the other hand, is regulated ubiquitously by a set of complexes containing the structurally distinct B-type cyclins (Booher et al. 1989; Moreno et al. 1989; Murray and Kirschner...
