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  Monoclonal antibodies inhibit the adhesion of mouse B 16 melanoma cells in vitro and block lung metastasis in vivo

Vollmers, H., & Birchmeier, W. (1983). Monoclonal antibodies inhibit the adhesion of mouse B 16 melanoma cells in vitro and block lung metastasis in vivo. Proceedings of the National Academy of Sciences of the United States of America, 80(12), 3729-3733. doi:10.1073/pnas.80.12.3729.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000C-03B6-3 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000C-03B7-2
Genre: Zeitschriftenartikel

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 Urheber:
Vollmers, HP1, Autor           
Birchmeier, W1, Autor           
Affiliations:
1Birchmeier Group, Friedrich Miescher Laboratory, Max Planck Society, ou_3480812              

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Schlagwörter: -
 Zusammenfassung: Seven monoclonal antibodies against mouse B 16 melanoma cells (produced in syngeneic C57BL/6 mice) were selected that blocked the adhesion of melanoma cells to tissue culture dishes. These antibodies were found to be directed against antigens on the surface of mouse B 16 melanoma cells but not on normal mouse cells such as 3T3 fibroblasts. Similarly, the antigens could not be detected in normal mouse tissues (e.g., lung, kidney, liver) but were found in lungs colonized by B 16 melanoma cells. Significantly, three of these antibodies virtually abolished lung colonization of highly invasive B 16 sublines injected into the animals' bloodstream. They exerted their effect both when preabsorbed by the melanoma cell in vitro and when delivered to the animals prior to the tumor cells. It is suggested that monoclonal antibodies might be a promising tool for preventing metastasis.

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 Datum: 1983-06
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1073/pnas.80.12.3729
PMID: 6574511
 Art des Abschluß: -

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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : PNAS
  Andere : Proceedings of the National Academy of Sciences of the USA
  Kurztitel : Proc. Natl. Acad. Sci. U. S. A.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 80 (12) Artikelnummer: - Start- / Endseite: 3729 - 3733 Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230