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  Chromosomal mapping of the structural gene coding for the mouse cell adhesion molecule uvomorulin

Eistetter, H., Adolph, S., Ringwald, M., Simon-Chazottes, D., Schuh, R., Guénet, J., et al. (1988). Chromosomal mapping of the structural gene coding for the mouse cell adhesion molecule uvomorulin. Proceedings of the National Academy of Sciences of the United States of America, 85(10), 3489-3493. doi:10.1073/pnas.85.10.3489.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-0572-E Version Permalink: https://hdl.handle.net/21.11116/0000-000F-2FE0-0
Genre: Journal Article

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 Creators:
Eistetter, HR1, Author           
Adolph, S, Author
Ringwald, M1, Author           
Simon-Chazottes, D, Author
Schuh, R, Author           
Guénet, JL, Author
Kemler, R1, Author           
Affiliations:
1Kemler Group, Friedrich Miescher Laboratory, Max Planck Society, ou_3481124              

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 Abstract: The gene coding for the mouse cell adhesion molecule uvomorulin has been mapped to chromosome 8. Uvomorulin cDNA clone F5H3 identified restriction fragment length polymorphisms in Southern blots of genomic DNA from mouse species Mus musculus domesticus and Mus spretus. By analyzing the segregation pattern of the gene in 75 offspring from an interspecific backcross a single genetic locus, Um, was defined on chromosome 8. Recombination frequency between Um and the co-segregating loci serum esterase 1 (Es-1) and tyrosine aminotransferase (Tat) places Um about 14 centimorgan (cM) distal to Es-1, and 5 cM proximal to Tat. In situ hybridization of uvomorulin [3H]cDNA to mouse metaphase chromosomes located the Um locus close to the distal end of chromosome 8 (bands C3-E1). Since uvomorulin is evolutionarily highly conserved, its chromosomal assignment adds an important marker to the mouse genetic map.

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 Dates: 1988-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1073/pnas.85.10.3489
PMID: 2897121
 Degree: -

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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : PNAS
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 85 (10) Sequence Number: - Start / End Page: 3489 - 3493 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230