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  No effect of subthalamic deep brain stimulation on metacognition in Parkinson’s disease

Trenado, C., Boschheidgen, M., N’Diaye, K., Schnitzler, A., Mallet, L., & Wojtecki, L. (2023). No effect of subthalamic deep brain stimulation on metacognition in Parkinson’s disease. Scientific Reports, 13: 10. doi:10.1038/s41598-022-26980-8.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-20AA-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-20AB-F
Genre: Journal Article

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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
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 Creators:
Trenado, Carlos1, 2, Author                 
Boschheidgen, Matthias2, Author
N’Diaye, Karim3, Author
Schnitzler, Alfons2, Author
Mallet, Luc3, 4, Author
Wojtecki, Lars2, 5, Author
Affiliations:
1Department of Music, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_2421696              
2Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany, ou_persistent22              
3Institut du Cerveau et de la Moelle Épinière, Hôpital Pitié-Salpêtrière, Paris, France, ou_persistent22              
4Department of Mental Health and Psychiatry, Global Health Institute, University of Geneva, Geneva, Switzerland, ou_persistent22              
5Departmemt of Neurology and Neurorehabilitation, Hospital Zum Heiligen Geist, Academic Teaching Hospital of the Heinrich-Heine-University Duesseldorf, von-Broichhausen-Allee 1, 47906, Kempen, Germany, ou_persistent22              

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Free keywords: Cognitive neuroscience, Movement disorders, Neuroscience, Parkinson's disease
 Abstract: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a powerful treatment in Parkinson’s disease (PD), which provides a positive effect on motor symptoms although the way it operates on high cognitive processes such as metacognition remains unclear. To address this issue, we recorded electroencephalogram (EEG) of PD patients treated with STN-DBS that performed a reversal learning (RL) paradigm endowed with metacognitive self-assessment. We considered two stimulation conditions, namely DBS-ON (stimulation on) and DBS-OFF (stimulation off), and focused our EEG-analysis on the frontal brain region due to its involvement on high cognitive processes. We found a trend towards a significant difference in RL ability between stimulation conditions. STN-DBS showed no effect on metacognition, although a significant association between accuracy and decision confidence level held for DBS OFF, but not in the case of DBS ON. In summary, our study revealed no significant effect of STN-DBS on RL or metacognition.

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Language(s): eng - English
 Dates: 2022-10-102022-12-222023-01-02
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41598-022-26980-8
 Degree: -

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 13 Sequence Number: 10 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322