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  Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia

Teller, J., Jung, C., Wilke, J. B. H., Schimmelpfennig, S.-D., Hindermann, M., Hinken, L., et al. (2022). Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia. Brain, Behavior, & Immunity - Health, 24: 100494. doi:10.1016/j.bbih.2022.100494.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-34D9-5 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-34DA-4
Genre: Journal Article

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1-s2.0-S2666354622000849-main.pdf (Publisher version), 523KB
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 Creators:
Teller, Johannes, Author
Jung, Carolin, Author
Wilke, Justus B. H.1, Author           
Schimmelpfennig, Svea-Dorothée, Author
Hindermann, Martin1, Author           
Hinken, Lukas, Author
Gabriel, Maria M., Author
Fegbeutel, Christine, Author
Schäfer, Andreas, Author
Laser, Hans, Author
Lichtinghagen, Ralf, Author
Worthmann, Hans, Author
Weissenborn, Karin, Author
Ehrenreich, Hannelore1, Author           
Affiliations:
1Research Group of Clinical Neuroscience, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350303              

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Free keywords: Blood-brain-barrier opening BBB breakdown Seroprevalence Serum proteins Immunoglobulin class Cardiac surgery Heart disease
 Abstract: Anesthetics penetrate the blood-brain-barrier (BBB) and - as confirmed preclinically – transiently disrupt it. An analogous consequence in humans has remained unproven. In mice, we previously reported that upon BBB dysfunction, the brain acts as ‘immunoprecipitator’ of autoantibodies against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB). We thus hypothesized that during human anesthesia, pre-existing NMDAR1-AB will specifically bind to brain. Screening of N = 270 subjects undergoing general anesthesia during cardiac surgery for serum NMDAR1-AB revealed N = 25 NMDAR1-AB seropositives. Only N = 14 remained positive post-surgery. No changes in albumin, thyroglobulin or CRP were associated with reduction of serum NMDAR1-AB. Thus, upon anesthesia, BBB opening likely occurs also in humans.

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Language(s): eng - English
 Dates: 2022-10
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.bbih.2022.100494
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Project name : This work was funded by the Else Kröner-Fresenius-Stiftung within the structured doctorate program KlinStrucMed of Hannover Medical School as well as by the Max Planck Society and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) TRR 274/1 2020 - 408885537.
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Title: Brain, Behavior, & Immunity - Health
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier B.V.
Pages: - Volume / Issue: 24 Sequence Number: 100494 Start / End Page: - Identifier: Other: ISSN
CoNE: https://pure.mpg.de/cone/journals/resource/2666-3546