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  Chemotaxis and autoinducer-2 signalling mediate colonization and contribute to co-existence of Escherichia coli strains in the murine gut.

Laganenka, L., Lee, J.-W., Malfertheiner, L., Dieterich, C. L., Fuchs, L., Piel, J., et al. (2023). Chemotaxis and autoinducer-2 signalling mediate colonization and contribute to co-existence of Escherichia coli strains in the murine gut. Nature Microbiology, 8(2), 207-214. doi:10.1038/s41564-022-01286-7.

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Laganenka, Leanid1, Author
Lee, Jae-Woo2, Author           
Malfertheiner, Lukas1, Author
Dieterich, Cora Lisbeth1, Author
Fuchs, Lea1, Author
Piel, Jorn1, Author
von Mering, Christian1, Author
Sourjik, Victor2, 3, Author                 
Hardt, Wolf-Dietrich1, Author
Affiliations:
1external, ou_persistent22              
2Microbial Networks, Department of Systems and Synthetic Microbiology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, ou_3266309              
3Center for Synthetic Microbiology (SYNMIKRO), Philipps-Universität Marburg, ou_persistent22              

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 Abstract: Bacteria communicate and coordinate their behaviour at the intra- and interspecies levels by producing and sensing diverse extracellular small molecules called autoinducers. Autoinducer 2 (AI-2) is produced and detected by a variety of bacteria and thus plays an important role in interspecies communication and chemotaxis. Although AI-2 is a major autoinducer molecule present in the mammalian gut and can influence the composition of the murine gut microbiota, its role in bacteria-bacteria and bacteria-host interactions during gut colonization remains unclear. Combining competitive infections in C57BL/6 mice with microscopy and bioinformatic approaches, we show that chemotaxis (cheY) and AI-2 signalling (via lsrB) promote gut colonization by Escherichia coli, which is in turn connected to the ability of the bacteria to utilize fructoselysine (frl operon). We further show that the genomic diversity of E. coli strains with respect to AI-2 signalling allows ecological niche segregation and stable co-existence of different E. coli strains in the mammalian gut. © 2023. The Author(s), under exclusive licence to Springer Nature Limited.

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 Dates: 2023
 Publication Status: Issued
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 Identifiers: ISI: 36624229
DOI: 10.1038/s41564-022-01286-7
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Title: Nature Microbiology
  Abbreviation : Nat. Microbiol.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 8 (2) Sequence Number: - Start / End Page: 207 - 214 Identifier: ISSN: 2058-5276
CoNE: https://pure.mpg.de/cone/journals/resource/2058-5276