A meta-analysis of pre-pregnancy maternal body mass index and placental DNA 
methylation identifies 27 CpG sites with implications for mother-child health

Fernandez-Jimenez, Nora; Fore, Ruby; Cilleros-Portet, Ariadna; Lepeule, Johanna; Perron, Patrice; Kvist, Tuomas; Tian, Fu-Ying; Lesseur, Corina; Binder, Alexandra M.; Lozano, Manuel; Martorell-Marugan, Jordi; Loke, Yuk J.; Bakulski, Kelly M.; Zhu, Yihui; Forhan, Anne; Sammallahti, Sara; Everson, Todd M.; Chen, Jia; Michels, Karin B.; Belmonte, Thalia; Carmona-Saez, Pedro; Halliday, Jane; Fallin, M. Daniele; LaSalle, Janine M.; Tost, Jorg; Czamara, Darina; Fernandez, Mariana F.; Gomez-Martin, Antonio; Craig, Jeffrey M.; Gonzalez-Alzaga, Beatriz; Schmidt, Rebecca J.; Dou, John F.; Muggli, Evelyne; Lacasana, Marina; Vrijheid, Martine; Marsit, Carmen J.; Karagas, Margaret R.; Raikkonen, Katri; Bouchard, Luigi; Heude, Barbara; Santa-Marina, Loreto; Bustamante, Mariona; Hivert, Marie-France; Bilbao, Jose Ramon

doi:10.1038/s42003-022-04267-y

A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health

Fernandez-Jimenez, N., Fore, R., Cilleros-Portet, A., Lepeule, J., Perron, P., Kvist, T., Tian, F.-Y., Lesseur, C., Binder, A. M., Lozano, M., Martorell-Marugan, J., Loke, Y. J., Bakulski, K. M., Zhu, Y., Forhan, A., Sammallahti, S., Everson, T. M., Chen, J., Michels, K. B., Belmonte, T., Carmona-Saez, P., Halliday, J., Fallin, M. D., LaSalle, J. M., Tost, J., Czamara, D., Fernandez, M. F., Gomez-Martin, A., Craig, J. M., Gonzalez-Alzaga, B., Schmidt, R. J., Dou, J. F., Muggli, E., Lacasana, M., Vrijheid, M., Marsit, C. J., Karagas, M. R., Raikkonen, K., Bouchard, L., Heude, B., Santa-Marina, L., Bustamante, M., Hivert, M.-F., & Bilbao, J. R. (2022). A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health. COMMUNICATIONS BIOLOGY, 5(1):. doi:10.1038/s42003-022-04267-y.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000C-4427-C 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000C-CEF5-8

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Fernandez-Jimenez, Nora, 著者
Fore, Ruby, 著者
Cilleros-Portet, Ariadna, 著者
Lepeule, Johanna, 著者
Perron, Patrice, 著者
Kvist, Tuomas, 著者
Tian, Fu-Ying, 著者
Lesseur, Corina, 著者
Binder, Alexandra M., 著者
Lozano, Manuel, 著者
Martorell-Marugan, Jordi, 著者
Loke, Yuk J., 著者
Bakulski, Kelly M., 著者
Zhu, Yihui, 著者
Forhan, Anne, 著者
Sammallahti, Sara, 著者
Everson, Todd M., 著者
Chen, Jia, 著者
Michels, Karin B., 著者
Belmonte, Thalia, 著者
Carmona-Saez, Pedro, 著者Halliday, Jane, 著者Fallin, M. Daniele, 著者LaSalle, Janine M., 著者Tost, Jorg, 著者Czamara, Darina¹, 著者 Fernandez, Mariana F., 著者Gomez-Martin, Antonio, 著者Craig, Jeffrey M., 著者Gonzalez-Alzaga, Beatriz, 著者Schmidt, Rebecca J., 著者Dou, John F., 著者Muggli, Evelyne, 著者Lacasana, Marina, 著者Vrijheid, Martine, 著者Marsit, Carmen J., 著者Karagas, Margaret R., 著者Raikkonen, Katri, 著者Bouchard, Luigi, 著者Heude, Barbara, 著者Santa-Marina, Loreto, 著者Bustamante, Mariona, 著者Hivert, Marie-France, 著者Bilbao, Jose Ramon, 著者全て表示

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1Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society, Kraepelinstr. 2-10, 80804 Munich, DE, ou_2035295

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要旨: Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ in fetal development and has been proposed to act as a mediator between the mother and different health outcomes in children. The overall aim of the present work is to investigate the association of ppBMI with epigenome-wide placental DNA methylation (DNAm) in 10 studies from the PACE consortium, amounting to 2631 mother-child pairs. We identify 27 CpG sites at which we observe placental DNAm variations of up to 2.0% per 10 ppBMI-unit. The CpGs that are differentially methylated in placenta do not overlap with CpGs identified in previous studies in cord blood DNAm related to ppBMI. Many of the identified CpGs are located in open sea regions, are often close to obesity-related genes such as GPX1 and LGR4 and altogether, are enriched in cancer and oxidative stress pathways. Our findings suggest that placental DNAm could be one of the mechanisms by which maternal obesity is associated with metabolic health outcomes in newborns and children, although further studies will be needed in order to corroborate these findings.
A meta-analysis of pre-pregnancy maternal body mass index (ppBMI) and placental DNA methylation from 2631 mother-child pairs identifies 27 CpG sites associated with ppBMI, providing insight into how maternal obesity could be associated with metabolic health outcomes in offspring.

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日付: オンライン出版: 2022

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識別子（DOI, ISBNなど）: ISI: 000890363700001
DOI: 10.1038/s42003-022-04267-y

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出版物名: COMMUNICATIONS BIOLOGY

種別: 学術雑誌

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ページ: - 巻号: 5 (1) 通巻号: 1313 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: -

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