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  Heart failure decouples the precuneus in interaction with social cognition and executive functions

Schroeter, M. L., Godulla, J., Thiel, F., Taskin, B., Beutner, F., Dubovoy, V. K., et al. (2023). Heart failure decouples the precuneus in interaction with social cognition and executive functions. Scientific Reports, 13(1): 1236. doi:10.1038/s41598-023-28338-0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-4617-C Version Permalink: https://hdl.handle.net/21.11116/0000-000D-0FDB-D
Genre: Journal Article

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 Creators:
Schroeter, Matthias L.1, 2, 3, Author           
Godulla, Jannis2, 4, Author
Thiel, Friederike1, 2, Author           
Taskin, Birol2, Author           
Beutner, Frank3, 5, Author
Dubovoy, Vladimir K.2, 6, Author
Teren, Andrej3, 5, 7, Author
Camilleri, Julia8, 9, Author
Eickhoff, Simon8, 9, Author
Villringer, Arno1, 2, 3, Author                 
Mueller, Karsten10, Author           
Affiliations:
1Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Ludwig Maximilians University Munich, Germany, ou_persistent22              
5Heart Center, Helios Hospital, Leipzig, Germany, ou_persistent22              
6Karazin Kharkiv National University, Ukraine, ou_persistent22              
7Department of Cardiology and Intensive Care Medicine, Medical School, University of Bielefeld, Germany, ou_persistent22              
8Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
9Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
10Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3282987              

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Free keywords: Coronary artery disease; Heart failure; Left ventricular ejection fraction; N-terminal prohormone of brain natriuretic peptide; Alzheimer’s disease; Functional magnetic resonance imaging; Precuneus
 Abstract: Aging increases the risk to develop Alzheimer’s disease. Cardiovascular diseases might accelerate this process. Our study aimed at investigating the impact of heart failure on brain connectivity using functional magnetic resonance imaging at resting state. Here we show brain connectivity alterations related to heart failure and cognitive performance. Heart failure decreases brain
connectivity in the precuneus. Precuneus dysconnectivity was associated with biomarkers of heart failure – left ventricular ejection fraction and N-terminal prohormone of brain natriuretic peptide – and cognitive performance, predominantly executive function. Meta-analytical data-mining
approaches – conducted in the BrainMap and Neurosynth databases – revealed that social and executive cognitive functions are mainly associated with those neural networks. Remarkably, the precuneus, as identified in our study in a mid-life cohort, represents one central functional hub affected by Alzheimer’s disease. A long-term follow-up investigation in our cohort after approximately nine years revealed more severe cognitive impairment in the group with heart failure than controls, where social cognition was the cognitive domain mainly affected, and not memory such as in Alzheimer’s disease. In sum, our results indicate consistently an association between heart failure and decoupling of the precuneus from other brain regions being associated
with social and executive functions. Further longitudinal studies are warranted elucidating
etiopathological mechanisms.

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Language(s): eng - English
 Dates: 2022-07-292023-01-172023-01-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41598-023-28338-0
PMID: 36690723
PMC: PMC9870947
 Degree: -

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Project name : -
Grant ID : CRC 1052 and SCHR 774/5-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : LIFE—Leipzig Research Center for Civilization Diseases, University Leipzig
Grant ID : -
Funding program : -
Funding organization : European Union, by the European Regional Development Fund (ERDF) and by means of the Free State of Saxony
Project name : TelDem
Grant ID : -
Funding program : eHealthSax Initiative
Funding organization : Sächsische Aufbaubank (SAB)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Saxon state parliament
Project name : -
Grant ID : -
Funding program : -
Funding organization : Projekt DEAL

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 13 (1) Sequence Number: 1236 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322