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Abstract:
The cAMP-PDE∗ released into the medium of cultures during growth is inhibited by a factor which is produced early in the phase of transition from growth to cell aggregation. In a non-aggregating mutant, active PDE is over-produced and not depressed in this developmental stage, although the enzyme is sensitive to wild-type inhibitor. In two other mutants, only low PDE activities were measured throughout the growth and transition phases. The cAMP-PDE inhibition may trigger development by rising the external cAMP level.
