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  Local Tissue Interactions across the Dorsal Midline of the Forebrain Establish CNS Laterality

Concha, M., Russell, C., Regan, J., Tawk, M., Sidi, S., Gilmour, D., et al. (2003). Local Tissue Interactions across the Dorsal Midline of the Forebrain Establish CNS Laterality. Neuron, 39(3), 423-438. doi:10.1016/s0896-6273(03)00437-9.

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 Creators:
Concha, ML, Author
Russell, C, Author
Regan, JC, Author
Tawk, M, Author
Sidi, S1, Author                 
Gilmour, DT1, Author           
Kapsimali, M, Author
Sumoy, L, Author
Goldstone, K, Author
Amaya, E, Author
Kimelman, D, Author
Nicolson, T1, Author                 
Gründer, S, Author
Gomperts, M, Author
Clarke, JDW, Author
Wilson, SW, Author
Affiliations:
1Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375716              

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 Abstract: The mechanisms that establish behavioral, cognitive, and neuroanatomical asymmetries are poorly understood. In this study, we analyze the events that regulate development of asymmetric nuclei in the dorsal forebrain. The unilateral parapineal organ has a bilateral origin, and some parapineal precursors migrate across the midline to form this left-sided nucleus. The parapineal subsequently innervates the left habenula, which derives from ventral epithalamic cells adjacent to the parapineal precursors. Ablation of cells in the left ventral epithalamus can reverse laterality in wild-type embryos and impose the direction of CNS asymmetry in embryos in which laterality is usually randomized. Unilateral modulation of Nodal activity by Lefty1 can also impose the direction of CNS laterality in embryos with bilateral expression of Nodal pathway genes. From these data, we propose that laterality is determined by a competitive interaction between the left and right epithalamus and that Nodal signaling biases the outcome of this competition.

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 Dates: 2003-07
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/s0896-6273(03)00437-9
PMID: 12895418
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 39 (3) Sequence Number: - Start / End Page: 423 - 438 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565