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  Mapping myelin in white matter with T1-weighted/T2-weighted maps: Discrepancy with histology and other myelin MRI measures

Sandrone, S., Aiello, M., Cavaliere, C., Thiebaut de Schotten, M., Reimann, K., Troakes, C., et al. (2023). Mapping myelin in white matter with T1-weighted/T2-weighted maps: Discrepancy with histology and other myelin MRI measures. Brain Structure & Function, 228(2), 525-535. doi:10.1007/s00429-022-02600-z.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-7D6E-E Version Permalink: https://hdl.handle.net/21.11116/0000-000D-113D-C
Genre: Journal Article

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 Creators:
Sandrone, Stefano1, 2, 3, Author
Aiello, Marco4, Author
Cavaliere, Carlo4, Author
Thiebaut de Schotten, Michel5, 6, Author
Reimann, Katja7, 8, Author
Troakes, Claire9, Author
Bodi, Istvan9, 10, Author
Lacerda, Luis11, 12, Author
Monti, Serena4, 13, Author
Murphy, Declan3, Author
Geyer, Stefan7, Author           
Catani, Marco3, 11, 12, Author
Dell’Acqua, Flavio2, 3, Author
Affiliations:
1Division of Brain Sciences, Faculty of Medicine, Imperial College London, United Kingdom, ou_persistent22              
2NatBrainLab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
3Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
4IRCCS SYNLAB SDN, Naples, Italy, ou_persistent22              
5Brain Connectivity and Behaviour Laboratory, Université Paris-Sorbonne, France, ou_persistent22              
6Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, Université de Bordeaux, France, ou_persistent22              
7Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
8Paul Flechsig Institute for Brain Research, University of Leipzig, Germany, ou_persistent22              
9Department of Basic and Clinical Neuroscience, King’s College London, United Kingdom, ou_persistent22              
10Clinical Neuropathology, King’s College London, United Kingdom, ou_persistent22              
11Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
12Developmental Imaging and Biophysics Section, UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, ou_persistent22              
13Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy, ou_persistent22              

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Free keywords: Corpus callosum; Myelin mapping; Myelin water fraction; Neuroanatomy; Neuroimaging; Quantitative susceptibility mapping; Validation
 Abstract: The ratio of T1-weighted/T2-weighted magnetic resonance images (T1w/T2w MRI) has been successfully applied at the cortical level since 2011 and is now one of the most used myelin mapping methods. However, no reports have explored the histological validity of T1w/T2w myelin mapping in white matter. Here we compare T1w/T2w with ex vivo postmortem histology and in vivo MRI methods, namely quantitative susceptibility mapping (QSM) and multi-echo T2 myelin water fraction (MWF) mapping techniques. We report a discrepancy between T1w/T2w myelin maps of the human corpus callosum and the histology and analyse the putative causes behind such discrepancy. T1w/T2w does not positively correlate with Luxol Fast Blue (LFB)-Optical Density but shows a weak to moderate, yet significant, negative correlation. On the contrary, MWF is strongly and positively correlated with LFB, whereas T1w/T2w and MWF maps are weakly negatively correlated. The discrepancy between T1w/T2w MRI maps, MWF and histological myelin maps suggests caution in using T1w/T2w as a white matter mapping method at the callosal level. While T1w/T2w imaging may correlate with myelin content at the cortical level, it is not a specific method to map myelin density in white matter.

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Language(s): eng - English
 Dates: 2022-03-182022-11-182023-01-242023-03
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s00429-022-02600-z
Other: epub 2023
PMID: 36692695
 Degree: -

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Project name : -
Grant ID : 103759/Z/14/Z
Funding program : -
Funding organization : Wellcome Trust
Project name : -
Grant ID : 818521
Funding program : Horizon 2020
Funding organization : European Research Council (ERC)
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Funding organization : National Institute for Health Research (NIHR) Biomedical Research Centre at South London
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Funding program : -
Funding organization : Maudsley NHS Foundation Trust
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Funding organization : King’s College London
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Funding program : -
Funding organization : Medical Research Council (MRC)
Project name : -
Grant ID : -
Funding program : Brains for Dementia Research programme
Funding organization : Alzheimer’s Research UK and Alzheimer’s Society
Project name : -
Grant ID : -
Funding program : -
Funding organization : Sackler Institute for Translational Neurodevelopment
Project name : -
Grant ID : -
Funding program : University of Bordeaux
Funding organization : French government

Source 1

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Title: Brain Structure & Function
  Abbreviation : Brain Struct Funct
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Berlin : Springer
Pages: - Volume / Issue: 228 (2) Sequence Number: - Start / End Page: 525 - 535 Identifier: ISSN: 1863-2653
CoNE: https://pure.mpg.de/cone/journals/resource/1863-2653