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  Mapping myelin in white matter with T1-weighted/T2-weighted maps: Discrepancy with histology and other myelin MRI measures

Sandrone, S., Aiello, M., Cavaliere, C., Thiebaut de Schotten, M., Reimann, K., Troakes, C., et al. (2023). Mapping myelin in white matter with T1-weighted/T2-weighted maps: Discrepancy with histology and other myelin MRI measures. Brain Structure & Function, 228(2), 525-535. doi:10.1007/s00429-022-02600-z.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000C-7D6E-E Versions-Permalink: https://hdl.handle.net/21.11116/0000-000F-6DB9-7
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 Urheber:
Sandrone, Stefano1, 2, 3, Autor
Aiello, Marco4, Autor
Cavaliere, Carlo4, Autor
Thiebaut de Schotten, Michel5, 6, Autor
Reimann, Katja7, 8, Autor
Troakes, Claire9, Autor
Bodi, Istvan9, 10, Autor
Lacerda, Luis11, 12, Autor
Monti, Serena4, 13, Autor
Murphy, Declan3, Autor
Geyer, Stefan7, Autor           
Catani, Marco3, 11, 12, Autor
Dell’Acqua, Flavio2, 3, Autor
Affiliations:
1Division of Brain Sciences, Faculty of Medicine, Imperial College London, United Kingdom, ou_persistent22              
2NatBrainLab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
3Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
4IRCCS SYNLAB SDN, Naples, Italy, ou_persistent22              
5Brain Connectivity and Behaviour Laboratory, Université Paris-Sorbonne, France, ou_persistent22              
6Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, Université de Bordeaux, France, ou_persistent22              
7Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
8Paul Flechsig Institute for Brain Research, University of Leipzig, Germany, ou_persistent22              
9Department of Basic and Clinical Neuroscience, King’s College London, United Kingdom, ou_persistent22              
10Clinical Neuropathology, King’s College London, United Kingdom, ou_persistent22              
11Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
12Developmental Imaging and Biophysics Section, UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, ou_persistent22              
13Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy, ou_persistent22              

Inhalt

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Schlagwörter: Corpus callosum; Myelin mapping; Myelin water fraction; Neuroanatomy; Neuroimaging; Quantitative susceptibility mapping; Validation
 Zusammenfassung: The ratio of T1-weighted/T2-weighted magnetic resonance images (T1w/T2w MRI) has been successfully applied at the cortical level since 2011 and is now one of the most used myelin mapping methods. However, no reports have explored the histological validity of T1w/T2w myelin mapping in white matter. Here we compare T1w/T2w with ex vivo postmortem histology and in vivo MRI methods, namely quantitative susceptibility mapping (QSM) and multi-echo T2 myelin water fraction (MWF) mapping techniques. We report a discrepancy between T1w/T2w myelin maps of the human corpus callosum and the histology and analyse the putative causes behind such discrepancy. T1w/T2w does not positively correlate with Luxol Fast Blue (LFB)-Optical Density but shows a weak to moderate, yet significant, negative correlation. On the contrary, MWF is strongly and positively correlated with LFB, whereas T1w/T2w and MWF maps are weakly negatively correlated. The discrepancy between T1w/T2w MRI maps, MWF and histological myelin maps suggests caution in using T1w/T2w as a white matter mapping method at the callosal level. While T1w/T2w imaging may correlate with myelin content at the cortical level, it is not a specific method to map myelin density in white matter.

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Sprache(n): eng - English
 Datum: 2022-03-182022-11-182023-01-242023-03
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1007/s00429-022-02600-z
Anderer: epub 2023
PMID: 36692695
 Art des Abschluß: -

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Projektinformation

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Projektname : -
Grant ID : 103759/Z/14/Z
Förderprogramm : -
Förderorganisation : Wellcome Trust
Projektname : -
Grant ID : 818521
Förderprogramm : Horizon 2020
Förderorganisation : European Research Council (ERC)
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Förderorganisation : National Institute for Health Research (NIHR) Biomedical Research Centre at South London
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Förderorganisation : Maudsley NHS Foundation Trust
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Förderprogramm : -
Förderorganisation : King’s College London
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Förderprogramm : -
Förderorganisation : Medical Research Council (MRC)
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Förderprogramm : Brains for Dementia Research programme
Förderorganisation : Alzheimer’s Research UK and Alzheimer’s Society
Projektname : -
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Förderprogramm : -
Förderorganisation : Sackler Institute for Translational Neurodevelopment
Projektname : -
Grant ID : -
Förderprogramm : University of Bordeaux
Förderorganisation : French government

Quelle 1

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Titel: Brain Structure & Function
  Kurztitel : Brain Struct Funct
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Berlin : Springer
Seiten: - Band / Heft: 228 (2) Artikelnummer: - Start- / Endseite: 525 - 535 Identifikator: ISSN: 1863-2653
CoNE: https://pure.mpg.de/cone/journals/resource/1863-2653