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  Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity

Di Russo, J., Young, J. L., Wegner, J. W. R., Steins, T., Kessler, H., & Spatz, J. P. (2021). Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity. eLife, 10: e69861, pp. 1-18. doi:10.7554/eLife.69861.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-819C-2 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-819D-1
Genre: Journal Article
Alternative Title : Integrin alpha5beta1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity

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 Creators:
Di Russo, Jacopo1, Author           
Young, Jennifer L.1, Author           
Wegner, Julian W. R.2, Author           
Steins, Timmy, Author
Kessler, Horst, Author
Spatz, Joachim P.1, 3, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              
3Max Planck School Matter to Life, Max Planck Schools, Max Planck Society, ou_3473638              

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Free keywords: cell biology; collective cell migration; human; integrin α5β1; keratocytes; physics of living systems; wound healing
 Abstract: Nanometer-scale properties of the extracellular matrix influence many biological processes, including cell motility. While much information is available for single-cell migration, to date, no knowledge exists on how the nanoscale presentation of extracellular matrix receptors influences collective cell migration. In wound healing, basal keratinocytes collectively migrate on a fibronectin-rich provisional basement membrane to re-epithelialize the injured skin. Among other receptors, the fibronectin receptor integrin α5β1 plays a pivotal role in this process. Using a highly specific integrin α5β1 peptidomimetic combined with nanopatterned hydrogels, we show that keratinocyte sheets regulate their migration ability at an optimal integrin α5β1 nanospacing. This efficiency relies on the effective propagation of stresses within the cell monolayer independent of substrate stiffness. For the first time, this work highlights the importance of extracellular matrix receptor nanoscale organization required for efficient tissue regeneration.

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Language(s): eng - English
 Dates: 2021-04-232021-09-132021-09-23
 Publication Status: Published online
 Pages: 18
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: URI: https://pubmed.ncbi.nlm.nih.gov/34554089/
DOI: 10.7554/eLife.69861
 Degree: -

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 10 Sequence Number: e69861 Start / End Page: 1 - 18 Identifier: Other: URL
ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X