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  Deep brain stimulation of the ventrointermediate nucleus of the thalamus to treat essential tremor improves motor sequence learning

Terzic, L., Voegtle, A., Farahat, A., Hartong, N., Galazky, I., Nasuto, S. J., et al. (2022). Deep brain stimulation of the ventrointermediate nucleus of the thalamus to treat essential tremor improves motor sequence learning. Human Brain Mapping, 43(15), 4791-4799. doi:10.1002/hbm.25989.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000C-867C-2 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000C-867D-1
Genre: Zeitschriftenartikel

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Terzic_2022_DeepBrainStimulation.pdf (Verlagsversion), 2MB
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https://hdl.handle.net/21.11116/0000-000C-867E-0
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Terzic_2022_DeepBrainStimulation.pdf
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OA-Status:
Gold
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Öffentlich
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application/pdf / [MD5]
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Copyright Datum:
2022
Copyright Info:
Copyright © 2022 The Authors
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http://creativecommons.org/licenses/by-nc-nd/3.0/

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https://onlinelibrary.wiley.com/doi/10.1002/hbm.25989 (Verlagsversion)
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 Urheber:
Terzic, Laila, Autor
Voegtle, Angela, Autor
Farahat, Amr1, 2, Autor
Hartong, Nanna, Autor
Galazky, Imke, Autor
Nasuto, Slawomir J., Autor
Andrade, Adriano de Oliveira, Autor
Knight, Robert T., Autor
Ivry, Richard B., Autor
Voges, Jürgen, Autor
Buentjen, Lars, Autor
Sweeney‐Reed, Catherine M., Autor
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Vinck Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381242              

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Schlagwörter: deep brain stimulation essential tremor motor sequence learning serial reaction time task ventrointermediate nucleus of the thalamus
 Zusammenfassung: The network of brain structures engaged in motor sequence learning comprises the same structures as those involved in tremor, including basal ganglia, cerebellum, thalamus, and motor cortex. Deep brain stimulation (DBS) of the ventrointermediate nucleus of the thalamus (VIM) reduces tremor, but the effects on motor sequence learning are unknown. We investigated whether VIM stimulation has an impact on motor sequence learning and hypothesized that stimulation effects depend on the laterality of electrode location. Twenty patients (age: 38–81 years; 12 female) with VIM electrodes implanted to treat essential tremor (ET) successfully performed a serial reaction time task, varying whether the stimuli followed a repeating pattern or were selected at random, during which VIM-DBS was either on or off. Analyses of variance were applied to evaluate motor sequence learning performance according to reaction times (RTs) and accuracy. An interaction was observed between whether the sequence was repeated or random and whether VIM-DBS was on or off (F[1,18] = 7.89, p = .012). Motor sequence learning, reflected by reduced RTs for repeated sequences, was greater with DBS on than off (T[19] = 2.34, p = .031). Stimulation location correlated with the degree of motor learning, with greater motor learning when stimulation targeted the lateral VIM (n = 23, ρ = 0.46; p = .027). These results demonstrate the beneficial effects of VIM-DBS on motor sequence learning in ET patients, particularly with lateral VIM electrode location, and provide evidence for a role for the VIM in motor sequence learning.

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 Datum: 2022-07-062022-09-21
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/hbm.25989
 Art des Abschluß: -

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Titel: Human Brain Mapping
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 43 (15) Artikelnummer: - Start- / Endseite: 4791 - 4799 Identifikator: ISSN: 1065-9471
ISSN: 1097-0193