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  Deep brain stimulation of the ventrointermediate nucleus of the thalamus to treat essential tremor improves motor sequence learning

Terzic, L., Voegtle, A., Farahat, A., Hartong, N., Galazky, I., Nasuto, S. J., et al. (2022). Deep brain stimulation of the ventrointermediate nucleus of the thalamus to treat essential tremor improves motor sequence learning. Human Brain Mapping, 43(15), 4791-4799. doi:10.1002/hbm.25989.

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Terzic_2022_DeepBrainStimulation.pdf (Publisher version), 2MB
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Terzic_2022_DeepBrainStimulation.pdf
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2022
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 Creators:
Terzic, Laila, Author
Voegtle, Angela, Author
Farahat, Amr1, 2, Author
Hartong, Nanna, Author
Galazky, Imke, Author
Nasuto, Slawomir J., Author
Andrade, Adriano de Oliveira, Author
Knight, Robert T., Author
Ivry, Richard B., Author
Voges, Jürgen, Author
Buentjen, Lars, Author
Sweeney‐Reed, Catherine M., Author
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Vinck Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381242              

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Free keywords: deep brain stimulation essential tremor motor sequence learning serial reaction time task ventrointermediate nucleus of the thalamus
 Abstract: The network of brain structures engaged in motor sequence learning comprises the same structures as those involved in tremor, including basal ganglia, cerebellum, thalamus, and motor cortex. Deep brain stimulation (DBS) of the ventrointermediate nucleus of the thalamus (VIM) reduces tremor, but the effects on motor sequence learning are unknown. We investigated whether VIM stimulation has an impact on motor sequence learning and hypothesized that stimulation effects depend on the laterality of electrode location. Twenty patients (age: 38–81 years; 12 female) with VIM electrodes implanted to treat essential tremor (ET) successfully performed a serial reaction time task, varying whether the stimuli followed a repeating pattern or were selected at random, during which VIM-DBS was either on or off. Analyses of variance were applied to evaluate motor sequence learning performance according to reaction times (RTs) and accuracy. An interaction was observed between whether the sequence was repeated or random and whether VIM-DBS was on or off (F[1,18] = 7.89, p = .012). Motor sequence learning, reflected by reduced RTs for repeated sequences, was greater with DBS on than off (T[19] = 2.34, p = .031). Stimulation location correlated with the degree of motor learning, with greater motor learning when stimulation targeted the lateral VIM (n = 23, ρ = 0.46; p = .027). These results demonstrate the beneficial effects of VIM-DBS on motor sequence learning in ET patients, particularly with lateral VIM electrode location, and provide evidence for a role for the VIM in motor sequence learning.

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 Dates: 2022-07-062022-09-21
 Publication Status: Issued
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.25989
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Title: Human Brain Mapping
Source Genre: Journal
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Pages: - Volume / Issue: 43 (15) Sequence Number: - Start / End Page: 4791 - 4799 Identifier: ISSN: 1065-9471
ISSN: 1097-0193