English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Induced cognitive impairments reversed by grafts of neural precursors: A longitudinal study in a macaque model of Parkinson's disease

Wianny, F., Dzahini, K., Fifel, K., Wilson, C. R. E., Bernat, A., Dolmazon, V., et al. (2022). Induced cognitive impairments reversed by grafts of neural precursors: A longitudinal study in a macaque model of Parkinson's disease. Advanced Science, 9(10): 2103827. doi:10.1002/advs.202103827.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-000C-85B5-1 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-85B6-0
Genre: Journal Article

Files

show Files
hide Files
:
Wianny_2022_InducedCognitiveImpairments.pdf (Publisher version), 9MB
View   Save
File Permalink:
https://hdl.handle.net/21.11116/0000-000C-85B7-F
Name:
Wianny_2022_InducedCognitiveImpairments.pdf
Description:
-
OA-Status:
Gold
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
2022
Copyright Info:
Copyright © 2022 The Authors
License:
http://creativecommons.org/licenses/by/3.0/

Locators

show
hide
Locator:
https://onlinelibrary.wiley.com/doi/10.1002/advs.202103827 (Publisher version)
Description:
-
OA-Status:
Gold

Creators

show
hide
 Creators:
Wianny, Florence, Author
Dzahini, Kwamivi, Author
Fifel, Karim, Author
Wilson, Charles Robert Eden, Author
Bernat, Agnieszka, Author
Dolmazon, Virginie, Author
Misery, Pierre, Author
Lamy, Camille, Author
Giroud, Pascale, Author
Cooper, Howard Michael, Author
Knoblauch, Kenneth, Author
Procyk, Emmanuel, Author
Kennedy, Henry, Author
Savatier, Pierre, Author
Dehay, Colette, Author
Vezoli, Julien1, 2, Author
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Fries Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381216              

Content

show
hide
Free keywords: circadian rhythms cognition and motor control embryonic stem cells neural precursors nonhuman primate low-dose MPTP
 Abstract: Parkinson's disease (PD) evolves over an extended and variable period in humans; years prior to the onset of classical motor symptoms, sleep and biological rhythm disorders develop, significantly impacting the quality-of-life of patients. Circadian-rhythm disorders are accompanied by mild cognitive deficits that progressively worsen with disease progression and can constitute a severe burden for patients at later stages. The gold-standard 6-methyl-1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) macaque model of PD recapitulates the progression of motor and nonmotor symptoms over contracted periods of time. Here, this multidisciplinary/multiparametric study follows, in five animals, the steady progression of motor and nonmotor symptoms and describes their reversal following grafts of neural precursors in diverse functional domains of the basal ganglia. Results show unprecedented recovery from cognitive symptoms in addition to a strong clinical motor recuperation. Both motor and cognitive recovery and partial circadian rhythm recovery correlate with the degree of graft integration, and in a subset of animals, with in vivo levels of striatal dopaminergic innervation and function. The present study provides empirical evidence that integration of neural precursors following transplantation efficiently restores function at multiple levels in parkinsonian nonhuman primates and, given interindividuality of disease progression and recovery, underlines the importance of longitudinal multidisciplinary assessments in view of clinical translation.

Details

show
hide
Language(s):
 Dates: 2022-02-092022-04-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/advs.202103827
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Advanced Science
  Other : Adv. Sci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 9 (10) Sequence Number: 2103827 Start / End Page: - Identifier: ISSN: 2198-3844
CoNE: https://pure.mpg.de/cone/journals/resource/2198-3844