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  Induced cognitive impairments reversed by grafts of neural precursors: A longitudinal study in a macaque model of Parkinson's disease

Wianny, F., Dzahini, K., Fifel, K., Wilson, C. R. E., Bernat, A., Dolmazon, V., et al. (2022). Induced cognitive impairments reversed by grafts of neural precursors: A longitudinal study in a macaque model of Parkinson's disease. Advanced Science, 9(10): 2103827. doi:10.1002/advs.202103827.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000C-85B5-1 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000C-85B6-0
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Wianny_2022_InducedCognitiveImpairments.pdf (Verlagsversion), 9MB
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https://hdl.handle.net/21.11116/0000-000C-85B7-F
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Wianny_2022_InducedCognitiveImpairments.pdf
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2022
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Copyright © 2022 The Authors
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https://onlinelibrary.wiley.com/doi/10.1002/advs.202103827 (Verlagsversion)
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 Urheber:
Wianny, Florence, Autor
Dzahini, Kwamivi, Autor
Fifel, Karim, Autor
Wilson, Charles Robert Eden, Autor
Bernat, Agnieszka, Autor
Dolmazon, Virginie, Autor
Misery, Pierre, Autor
Lamy, Camille, Autor
Giroud, Pascale, Autor
Cooper, Howard Michael, Autor
Knoblauch, Kenneth, Autor
Procyk, Emmanuel, Autor
Kennedy, Henry, Autor
Savatier, Pierre, Autor
Dehay, Colette, Autor
Vezoli, Julien1, 2, Autor
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Fries Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381216              

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Schlagwörter: circadian rhythms cognition and motor control embryonic stem cells neural precursors nonhuman primate low-dose MPTP
 Zusammenfassung: Parkinson's disease (PD) evolves over an extended and variable period in humans; years prior to the onset of classical motor symptoms, sleep and biological rhythm disorders develop, significantly impacting the quality-of-life of patients. Circadian-rhythm disorders are accompanied by mild cognitive deficits that progressively worsen with disease progression and can constitute a severe burden for patients at later stages. The gold-standard 6-methyl-1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) macaque model of PD recapitulates the progression of motor and nonmotor symptoms over contracted periods of time. Here, this multidisciplinary/multiparametric study follows, in five animals, the steady progression of motor and nonmotor symptoms and describes their reversal following grafts of neural precursors in diverse functional domains of the basal ganglia. Results show unprecedented recovery from cognitive symptoms in addition to a strong clinical motor recuperation. Both motor and cognitive recovery and partial circadian rhythm recovery correlate with the degree of graft integration, and in a subset of animals, with in vivo levels of striatal dopaminergic innervation and function. The present study provides empirical evidence that integration of neural precursors following transplantation efficiently restores function at multiple levels in parkinsonian nonhuman primates and, given interindividuality of disease progression and recovery, underlines the importance of longitudinal multidisciplinary assessments in view of clinical translation.

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 Datum: 2022-02-092022-04-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/advs.202103827
 Art des Abschluß: -

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Titel: Advanced Science
  Andere : Adv. Sci.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Weinheim : Wiley-VCH
Seiten: - Band / Heft: 9 (10) Artikelnummer: 2103827 Start- / Endseite: - Identifikator: ISSN: 2198-3844
CoNE: https://pure.mpg.de/cone/journals/resource/2198-3844