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  Inflammation-Controlled Anti-Inflammatory Hydrogels

Helmecke, T., Hahn, D., Matzke, N., Ferdinand, L., Franke, L., Kuehn, S., et al. (2023). Inflammation-Controlled Anti-Inflammatory Hydrogels. Advanced Science, 10(7): 2206412. doi:10.1002/advs.202206412.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-88EC-1 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-CB59-C
Genre: Journal Article

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Advanced Science - 2022 - Helmecke.pdf (Publisher version), 3MB
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Advanced Science - 2022 - Helmecke.pdf
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 Creators:
Helmecke, Tina, Author
Hahn, Dominik, Author
Matzke, Nadine, Author
Ferdinand, Lisa, Author
Franke, Lars1, Author
Kuehn, Sebastian, Author
Fischer, Gunter1, Author
Werner, Carsten, Author
Maitz, Manfred F., Author
Affiliations:
1Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3349219              

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 Abstract: While autoregulative adaptation is a common feature of living tissues, only a few feedback-controlled adaptive biomaterials are available so far. This paper herein reports a new polymer hydrogel platform designed to release anti-inflammatory molecules in response to the inflammatory activation of human blood. In this system, anti-inflammatory peptide drugs, targeting either the complement cascade, a complement receptor, or cyclophilin A, are conjugated to the hydrogel by a peptide sequence that is cleaved by elastase released from activated granulocytes. As a proof of concept, the adaptive drug delivery from the gel triggered by activated granulocytes and the effect of the released drug on the respective inflammatory pathways are demonstrated. Adjusting the gel functionalization degree is shown to allow for tuning the drug release profiles to effective doses within a micromolar range. Feedback-controlled delivery of covalently conjugated drugs from a hydrogel matrix is concluded to provide valuable safety features suitable to equip medical devices with highly active anti-inflammatory agents without suppressing the general immunosurveillance.

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Language(s): eng - English
 Dates: 2022-12-292023-03-03
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/advs.202206412
 Degree: -

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Project name : The research was funded by the Federal Ministry of Education and Research (BMBF) within the project Zwanzig20 RESPONSE–Partnerschaft für Innovation in der Implantattechnologie.
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Title: Advanced Science
  Other : Adv. Sci.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 10 (7) Sequence Number: 2206412 Start / End Page: - Identifier: ISSN: 2198-3844
CoNE: https://pure.mpg.de/cone/journals/resource/2198-3844