Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Neutral models of de novo gene emergence suggest that gene evolution has a preferred trajectory

Iyengar, B., & Bornberg-Bauer, E. (2023). Neutral models of de novo gene emergence suggest that gene evolution has a preferred trajectory. Molecular Biology and Evolution, 40(4): msad079. doi:10.1093/molbev/msad079.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Iyengar, BR, Autor
Bornberg-Bauer, E1, Autor                 
Affiliations:
1Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society, ou_3371683              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: New protein coding genes can emerge from genomic regions that previously did not contain any genes, via a process called de novo gene emergence. To synthesize a protein, DNA must be transcribed as well as translated. Both processes need certain DNA sequence features. Stable transcription requires promoters and a polyadenylation signal, while translation requires at least an open reading frame (ORF). We develop mathematical models based on mutation probabilities, and the assumption of neutral evolution, to find out how quickly genes emerge and are lost. We also investigate the effect of the order by which DNA features evolve, and if sequence composition is biased by mutation rate. We rationalize how genes are lost much more rapidly than they emerge, and how they preferentially arise in regions that are already transcribed. Our study not only answers some fundamental questions on the topic of de novo emergence but also provides a modeling framework for future studies.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2023-04
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1093/molbev/msad079
PMID: 37011142
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Molecular Biology and Evolution
  Andere : Mol. Biol. Evol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Oxford : Oxford University Press
Seiten: 17 Band / Heft: 40 (4) Artikelnummer: msad079 Start- / Endseite: - Identifikator: ISSN: 0737-4038
CoNE: https://pure.mpg.de/cone/journals/resource/954925536119