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  Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement

Burrows, P., Beck-Engeser, G., & Wabl, M. (1983). Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement. Nature, 306(5940), 243-246. doi:10.1038/306243a0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-A003-B Version Permalink: https://hdl.handle.net/21.11116/0000-000C-A004-A
Genre: Journal Article

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Burrows, PD1, Author           
Beck-Engeser, GB1, Author           
Wabl, M1, Author           
Affiliations:
1Wabl Group, Friedrich Miescher Laboratory, Max Planck Society, ou_3493116              

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 Abstract: Switching of an Abelson virus-transformed mouse lymphoid cell line from immunoglobulin μ to γ2b heavy-chain synthesis in vitro is accompanied by loss of DNA sequences between the JH and Cγ2b gene segments, and thus cannot be explained by differential RNA processing. The light-chain loci of both μ- and γ2b-producing cell clones are in the embryonic configuration, which indicates that class switching can occur in pre-B cells.

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 Dates: 1983-11
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1038/306243a0
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 306 (5940) Sequence Number: - Start / End Page: 243 - 246 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238