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  Immunoglobulin heavy chain toxicity in plasma cells is neutralized by fusion to pre-B cells

Haas, I., & Wabl, M. (1984). Immunoglobulin heavy chain toxicity in plasma cells is neutralized by fusion to pre-B cells. Proceedings of the National Academy of Sciences of the United States of America, 81(22), 7185-7188. doi:10.1073/pnas.81.22.7185.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-A049-D Version Permalink: https://hdl.handle.net/21.11116/0000-000C-A04A-C
Genre: Journal Article

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 Creators:
Haas, IG1, Author           
Wabl, MR1, Author           
Affiliations:
1Wabl Group, Friedrich Miescher Laboratory, Max Planck Society, ou_3493116              

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 Abstract: A plasma cell hybridoma frequently loses its immunoglobulin heavy (H) chain spontaneously but rarely is production of its light (L) chain lost. Upon fusion to a pre-B-cell hybridoma that produces no Ig chain, the L chain is frequently lost. In cells without the L chain the H chain, which is derived from the plasma cell, is not chemically modified. Our results indicate that, in pre-B cells, but not in plasma cells, there must be a mechanism that neutralizes the toxic effect of free H chain.

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 Dates: 1984-11
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1073/pnas.81.22.7185
PMID: 6438634
 Degree: -

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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : PNAS
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 81 (22) Sequence Number: - Start / End Page: 7185 - 7188 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230