English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  Transforming growth factor-beta inhibits endothelial cell proliferation

Fràter-Schröder, M., Müller, G., Birchmeier, W., & Böhlen, P. (1986). Transforming growth factor-beta inhibits endothelial cell proliferation. Biochemical and Biophysical Research Communications, 137(1), 295-302. doi:10.1016/0006-291x(86)91209-x.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-000C-A0C5-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-A0C6-F
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Fràter-Schröder, M, Author
Müller, G1, Author           
Birchmeier, W1, Author           
Böhlen, P, Author
Affiliations:
1Birchmeier Group, Friedrich Miescher Laboratory, Max Planck Society, ou_3480812              

Content

show
hide
Free keywords: -
 Abstract: Transforming growth factor-beta (TGF-beta) is an inhibitor of the proliferation of bovine aortic endothelial cells in culture. Basal cell growth in serum-containing medium and cell proliferation stimulated by fibroblast growth factor (FGF) are inhibited by TGF-beta in a dose-dependent manner. Half-maximal inhibition occurs at an inhibitor concentration of 0.5-1.0 ng/ml. TGF-beta does not appear to be cytotoxic and cells treated with the inhibitor grow normally after removal of TGF-beta. High concentrations of FGF are ineffective in overcoming TGF-beta-induced inhibition of cell proliferation, suggesting that antagonism of growth factor-induced cell proliferation by TGF-beta is of a noncompetitive nature.

Details

show
hide
Language(s):
 Dates: 1986-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/0006-291x(86)91209-x
PMID: 3459460
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Biochemical and Biophysical Research Communications
  Other : Biochem. Biophys. Res. Commun.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 137 (1) Sequence Number: - Start / End Page: 295 - 302 Identifier: ISSN: 0006-291X
CoNE: https://pure.mpg.de/cone/journals/resource/954922652205_1