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  Correction: Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine

Danyeli, L., Sen, Z., Colic, L., Kurzweil, L., Gensberger-Reigl, S., Macharadze, T., et al. (2023). Correction: Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine. Translational Psychiatry, 13(1): 73. doi:10.1038/s41398-023-02377-7.

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 Creators:
Danyeli, LV, Author
Sen, ZD, Author
Colic, L, Author
Kurzweil, L, Author
Gensberger-Reigl, S, Author
Macharadze, T, Author
Götting, F, Author
Refisch, A, Author
Liebe, T, Author
Chand, T, Author           
Kretzschmar, M, Author
Wagner, G, Author
Opel, N, Author
Jollant, F, Author
Speck, O, Author
Munk, MHJ, Author           
Li, M, Author           
Walter, M1, Author           
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Ketamine shows rapid antidepressant effects peaking 24 h after administration. The antidepressant effects may occur through changes in glutamatergic metabolite levels and resting-state functional connectivity (rsFC) within the default mode network (DMN). A multistage drug effect of ketamine has been suggested, inducing acute effects on dysfunctional network configuration and delayed effects on homeostatic synaptic plasticity. Whether the DMN-centered delayed antidepressant-related changes are associated with the immediate changes remains unknown. Thirty-five healthy male participants (25.1 ± 4.2 years) underwent 7 T magnetic resonance spectroscopy (MRS) and resting-state functional magnetic resonance imaging (rsfMRI) before, during, and 24 h after a single S-ketamine or placebo infusion. Changes in glutamatergic measures and rsFC in the DMN node pregenual anterior cingulate cortex (pgACC) were examined. A delayed rsFC decrease of the pgACC to inferior parietal lobe (family-wise error corrected p (pFWEc) = 0.018) and dorsolateral prefrontal cortex (PFC; pFWEc = 0.002) was detected that was preceded by an immediate rsFC increase of the pgACC to medial PFC (pFWEc < 0.001) and dorsomedial PFC (pFWEc = 0.005). Additionally, the immediate rsFC reconfigurations correlated with the delayed pgACC glutamate (Glu) level increase (p = 0.024) after 24 h at trend level (p = 0.067). Baseline measures of rsFC and MRS were furthermore associated with the magnitude of the respective delayed changes (p's < 0.05). In contrast, the delayed changes were not associated with acute psychotomimetic side effects or plasma concentrations of ketamine and its metabolites. This multimodal study suggests an association between immediate S-ketamine-induced network effects and delayed brain changes at a time point relevant in its clinical context.

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 Dates: 2023-02
 Publication Status: Issued
 Pages: -
 Publishing info: -
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 Rev. Type: -
 Identifiers: DOI: 10.1038/s41398-023-02377-7
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Title: Translational Psychiatry
  Abbreviation : Transl Psychiatry
Source Genre: Journal
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Publ. Info: Nature Pub. Group
Pages: 1 Volume / Issue: 13 (1) Sequence Number: 73 Start / End Page: - Identifier: ISSN: 2158-3188
CoNE: https://pure.mpg.de/cone/journals/resource/2158-3188