日本語
 
Help Privacy Policy ポリシー/免責事項
  詳細検索ブラウズ

アイテム詳細

登録内容を編集ファイル形式で保存
一時保存へ追加
 タグ情報を表示リリース履歴を表示詳細要約
  Reliability of spinal cord measures based on synthetic T1-weighted MRI derived from multiparametric mapping (MPM)

Schading, S., Seif, M., Leutritz, T., Hupp, M., Curt, A., Weiskopf, N., & Freund, P. (2023). Reliability of spinal cord measures based on synthetic T1-weighted MRI derived from multiparametric mapping (MPM). NeuroImage, 271:. doi:10.1016/j.neuroimage.2023.120046.

Item is

 

表示: 全項目 非表示: 全項目

基本情報

表示: 非表示:
アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000C-DA75-B 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-05BF-7
資料種別: 学術論文

ファイル

表示: ファイル
非表示: ファイル
:
Schading_2023.pdf (出版社版), 2MB
表示   保存
ファイルのパーマリンク:
https://hdl.handle.net/21.11116/0000-000C-DA77-9
ファイル名:
Schading_2023.pdf
説明:
-
OA-Status:
Gold
閲覧制限:
公開
MIMEタイプ / チェックサム:
application/pdf / [MD5]
技術的なメタデータ:
表示
著作権日付:
-
著作権情報:
-
CCライセンス:
https://creativecommons.org/licenses/by/4.0/

関連URL

表示:

作成者

表示:
非表示:
 作成者:
Schading, Simon1, 著者
Seif, Maryam1, 2, 著者           
Leutritz, Tobias2, 著者                 
Hupp, Markus1, 著者
Curt, Armin1, 著者
Weiskopf, Nikolaus2, 3, 著者                 
Freund, Patrick1, 2, 4, 著者                 
所属:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              

内容説明

表示:
非表示:
キーワード: Synthetic T1-weighted MRI; Quantitative MRI; Neurodegeneration; Spinal cord injury; Cervical cord atrophy
 要旨: Short MRI acquisition time, high signal-to-noise ratio, and high reliability are crucial for image quality when scanning healthy volunteers and patients. Cross-sectional cervical cord area (CSA) has been suggested as a marker of neurodegeneration and potential outcome measure in clinical trials and is conventionally measured on T1-weigthed 3D Magnetization Prepared Rapid Acquisition Gradient-Echo (MPRAGE) images. This study aims to reduce the acquisition time for the comprehensive assessment of the spinal cord, which is typically based on MPRAGE for morphometry and multi-parameter mapping (MPM) for microstructure. The MPRAGE is replaced by a synthetic T1-w MRI (synT1-w) estimated from the MPM, in order to measure CSA. SynT1-w images were reconstructed using the MPRAGE signal equation based on quantitative maps of proton density (PD), longitudinal (R1) and effective transverse (R2*) relaxation rates. The reliability of CSA measurements from synT1-w images was determined within a multi-center test-retest study format and validated against acquired MPRAGE scans by assessing the agreement between both methods. The response to pathological changes was tested by longitudinally measuring spinal cord atrophy following spinal cord injury (SCI) for synT1-w and MPRAGE using linear mixed effect models. CSA measurements based on the synT1-w MRI showed high intra-site (Coefficient of variation [CoV]: 1.43% to 2.71%) and inter-site repeatability (CoV: 2.90% to 5.76%), and only a minor deviation of -1.65 mm2 compared to MPRAGE. Crucially, by assessing atrophy rates and by comparing SCI patients with healthy controls longitudinally, differences between synT1-w and MPRAGE were negligible. These results demonstrate that reliable estimates of CSA can be obtained from synT1-w images, thereby reducing scan time significantly.

資料詳細

表示:
非表示:
言語: eng - English
 日付: 2023-03-142023-01-062023-03-182023-03-212023-05-01
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: DOI: 10.1016/j.neuroimage.2023.120046
その他: epub 2023
PMID: 36948280
 学位: -

関連イベント

表示:

訴訟

表示:

Project information

表示: 非表示:
Project name : -
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : 15.0137
Funding program : -
Funding organization : Swiss State Secretariat for Education, Research and Innovation (SERI)
Project name : -
Grant ID : 32NE30_173,678
Funding program : -
Funding organization : ERA-NET Neuron
Project name : -
Grant ID : 323,530_207,038; 181,362
Funding program : -
Funding organization : Swiss National Science Foundation (SNSF)
Project name : -
Grant ID : WFL-CH-19/20
Funding program : -
Funding organization : Wings for Life Charity
Project name : -
Grant ID : IRP-158
Funding program : -
Funding organization : International Foundation for Research in Paraplegia (IRP)
Project name : -
Grant ID : WE 5046/4–2
Funding program : (347,592,254)
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : 01ED2210
Funding program : -
Funding organization : Federal Ministry of Education and Research (BMBF)

出版物 1

表示:
非表示:
出版物名: NeuroImage
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Orlando, FL : Academic Press
ページ: - 巻号: 271 通巻号: 120046 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166